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Study on correlation of plasma cholesterol level and amyloid β level

LÜ Peng1, HU Ya-nan2, SHENG Hong-guang3   

  1. 1.Department of Geriatrics, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2.Clinical Research Center, Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; 3.Department of Endocrinology, Shanghai Xuhui District Central Hospital, Shanghai 200031, China
  • Online:2014-09-28 Published:2014-09-26


Objective To explore the correlation of the plasma cholesterol level and the plasma amyloid β (Aβ) level. Methods Among patients aged 50-65 years, 16 patients with borderline high cholesterol and 16 patients with high cholesterol were randomly selected as the high cholesterol group and 16 healthy subjects were randomly selected as the control group. The levels of plasma Aβ-40, Aβ-42, total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), and triglyceride (TG) of two groups were detected and their correlations were analyzed. Results The levels of plasma Aβ-40, Aβ-42, LDL-C, and TG of the high cholesterol group were significantly higher than those of the control group (P<0.01). The linear correlation analysis showed that for the control group, Aβ-40 and Aβ-42 did not correlate with TC, LDL-C, HDL-C, and TG. For the high cholesterol group, Aβ-40 and Aβ-42 positively correlated with TC (P<0.01 or P<0.05), and TC positively correlated with TG and LDL-C (P<0.01 or P<0.05) and negatively correlated with HDL (P<0.05). After TG, LDL-C, and HDL-C were adjusted, partial correlation analysis was performed for TC versus Aβ-40 and Aβ-42. The results showed that Aβ-40 and Aβ-42 still positively correlated with TC (P<0.05). Conclusion For patients with high cholesterol, the levels of plasma Aβ-40 and Aβ-42 significantly increase and the plasma Aβ level is correlated with plasma TC level.

Key words: amyloid β, cholesterol, correlation