Abstract:

Membrane lipids mainly include sphingolipid, glycerophospholipid, and cholesterol, which are abundant in brain. Currently, lots of researches have indicated that metabolic disturbance of membrane lipids in body is associated with pathophysiology in Alzheimer’s disease (AD), especially with abnormalities of amyloid β (Aβ) and its relevant metabolic enzyme. This article aims to review studies on the association of changes of membrane lipids with Aβ abnormality and provides new views and ideas for studies on the pathogenesis of AD from the perspective of membrane lipids metabolism.

Key words: membrane lipids, sphingolipid, glycerophospholipid, cholesterol, Alzheimer’s disease