›› 2018, Vol. 38 ›› Issue (3): 348-.doi: 10.3969/j.issn.1674-8115.2018.03.020

• Review • Previous Articles     Next Articles

Role of SUMO-specific proteases in tumor biological behavior

MIAO Hui-xian1 , LIU Zi-hao1 , LI Wei-ya1 , HUANG Da1 , LI Wen-bo1 , ZUO Yong2   

  1. 1. Shanghai Jiao Tong University School of Medicine, 2. Department of Biochemistry and Cell Biology, Shanghai Jiao Tong University College of Basic Medical Sciences, Shanghai 200025, China
  • Online:2018-03-28 Published:2018-05-03
  • Supported by:
    Shanghai Jiao Tong University School of Medicine Student Innovation Training Program

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Abstract: SUMOylation is a dynamically reversible process that needs to be modified by a specific ligase, while its inverse reaction deSUMOylation is catalyzed by a group of SUMO-specific proteases (SENPs). SUMO-modified target protein molecules are closely related to development and disease, especially tumor, metabolism, inflammation and immunity. SENPs play an important role in SUMO protein maturation and deSUMOylation. This review discussed the functions of SENPs in the development and progression of tumors and related mechanisms.

Key words: SUMO, SUMO-specific proteases (SENPs), tumor