Abstract: Objective · To investigate the relationship of hemoglobin A1c (HbA1c) with blood viscosity and peripheral arterial blood flow in patients with type 2 diabetes mellitus (T2DM). Methods · A total of 345 patients with T2DM were divided into four groups according to the HbA1c levels: group A (HbA1c≤ HbA1c≤ HbA1c≥ 10.0%, 77 cases). All patients were tested for blood glucose, HbA1c, blood viscosity and peripheral arterial ultrasound. Spearman and Pearson correlation as well as stepwise multivariate regression analyses were performed to analyze the data. Results · The whole blood viscosities at 1/s, 5/s, 30/s and 200/s shear rates of group B, C and D (HbA1c ≥ 7%) were significantly higher than those of group A (HbA1c≥ 8.5%) were significantly higher than those of group A and B (HbA1c(P(PPConclusion · The blood HbA1c levels in T2DM patients are positively correlated with blood viscosity, and HSRV, and negatively correlated with left and right internal carotid arterial inner diameters, but have no significant correlation with peripheral arterial blood flow velocity.

Key words: hemoglobin A1c (HbA1c), type 2 diabetes mellitus, blood viscosity；high shear reduction viscosity of whole blood, peripheral arterial ultrasound