›› 2019, Vol. 39 ›› Issue (9): 1083-.doi: 10.3969/j.issn.1674-8115.2019.09.023

• Review • Previous Articles     Next Articles

Role of gastrointestinal microbiota in tumorigenesis

LU Hai-yang, ZHAO Wei-li   

  1. Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Institute of Hematology; le P.le Sino-Fran.ais de Recherchesen Science du Vivant et Génomique, Shanghai 200025, China
  • Online:2019-09-28 Published:2019-11-02
  • Supported by:
    National Natural Science Foundation of China, 81325003, 81520108003, 81670716, 81201863; Project of Shanghai Science and Technology Committee, 14430723400, 14140903100, 16JC1405800; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20152206, 20152208)。

Abstract: Gastrointestinal microbiota has an important impact on physiological functions of human body. In recent years, the importance of gastrointestinal microbiota in tumorigenesis has emerged. Aberrant location and proportion of microbiota can canot only carcinogenesis of local epithelia, but also tumorigenesis in submucous tissues or even distant organs. Certain microbes can produce genotoxin or generate reactive oxygen species to caDNA damage and affect DNA damage repair, which leads to genetic instability and induces cell transformation. Moreover, gastrointestinal microbiota is able to affect the function of host immune system and form an immunosuppressive microenvironment, while some other pathogenic bacteria can cachronic inflammation and may be involved in tumor immune escape. Based on the above, gastrointestinal microbiota is oncogenic and closely linked to tumorigenesis.

Key words: gastrointestinal microbiota, malignancy, genetic instability, oxidative stress, inflammation

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