›› 2019, Vol. 39 ›› Issue (9): 1077-.doi: 10.3969/j.issn.1674-8115.2019.09.022

• Original article (Clinical research) • Previous Articles     Next Articles

Efficiency comparison of fasting plasma glucose combined with 1,5-anhydroglucitol and combined with glycated albumin in diabetes mellitus screening

SU Hang, MA Xiao-jing, YING Ling-wen, HE Xing-xing, ZHU Wei, TANG Jun-ling, WANG Yu-fei, BAO Yu-qian, ZHOU Jian   

  1. Department of Endocrinology and Metabolism, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus; Shanghai Clinical Center for Diabetes, Shanghai 200233, China
  • Online:2019-09-28 Published:2019-11-02
  • Supported by:
    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20161430)。

Abstract: Objective · To analyze and compare the clinical value of serum 1,5-anhydroglucitol (1,5-AG) with glycated albumin (GA) combined with fasting plasma glucose (FPG), respectively, in screening diabetes mellitus in Chinese population at the risk of diabetes mellitus. Methods · A total of 701 subjects with high risk of diabetes were enrolled in this study, including 324 males and 377 females. All subjects underwent 75 g oral glucose tolerance test (OGTT). Diabetes was diagnosed according to the cut-off points of 2010 American Diabetes Association standards. The sensitivity, specificity and area under ROC curve (AUC) of GA combined with FPG and 1,5-AG combined with FPG in screening diabetes mellitus were analyzed. Results · Among 701 subjects, 350 (49.93%) cases were diagnosed as having diabetes mellitus. The sensitivity, specificity, and AUC of 1,5-AG combined with FPG were 84.29%, 91.45% and 0.939, respectively. The sensitivity of GA combined with FPG was 77.71%, and the specificity and AUC were 90.88% and 0.932, respectively. There was no significant difference in AUC between the two screening methods (P>0.05), but the sensitivity of 1,5-AG combined with FPG was higher than that of GA combined with FPG (P0.001). The proportion of the subjects in need of further OGTT judged1,5-AG combined with FPG was 27.82%, which was 11.27% lower than that judgedFPG alone, and 2.57% lower than that judgedGA combined with FPG. Conclusion · In Chinese population with high risk of diabetes mellitus, serum 1,5-AG or GA combined with FPG can improve the efficiency of diabetes screening. Compared with GA combined with FPG, 1,5-AG combined with FPG may have more clinical value.

Key words: diabetes mellitus, 1,5-anhydroglucitol (1,5-AG), glycated albumin (GA), fasting plasma glucose (FPG), screening

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