›› 2020, Vol. 40 ›› Issue (2): 255-.doi: 10.3969/j.issn.1674-8115.2020.02.018

• Review • Previous Articles     Next Articles

Effect of cytoskeleton-associated protein 4 on tumor diagnosis and prognosis

LIU Jin-yan, ZHAO Jun-tao, WANG Heng-ru, HUANG Jia-yi, WANG Yu-ting, XIANG Ming-jie   

  1. 1. Radioimmunology and Clinical Laboratory, Luwan Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China; 2. Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2020-02-28 Published:2020-03-20
  • Supported by:
    National Natural Science Foundation of China (81871706); "Science and Technology Innovation Action Plan" Projects in Industry-University-Research-Medical Cooperation Fields of Shanghai (17DZ1930301-26); Shanghai Municipal Planning Commission of Science and Research Fund (201840227, 201740069); Shanghai Huangpu District Municipal Planning Commission of Science and Research Fund (HKM201702).

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Abstract: Cytoskeleton-associated protein 4 (CKAP4), also known as p63, is a non-glycosylated type Ⅱ membrane protein. Expression of CKAP4 in tissues, cells and serum can be used as a diagnostic marker for a variety of tumors, and has a certain correlation with the prognosis of these tumors. This article reviews the subtype and function of CKAP4, as well as its research and application as a diagnostic and prognostic indicator of tumor.

Key words: cytoskeleton-associated protein 4 (CKAP4), p63, tumor marker, diagnosis, prognosis