JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (6): 815-820.doi: 10.3969/j.issn.1674-8115.2021.06.019

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Recent progresses in deep brain stimulation of subthalamic nucleus on Parkinson′s disease and its related depression

Xiao-xiao ZHANG(), Chen-cheng ZHANG, Yi-jie LAI, Bo-min SUN()   

  1. Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2021-06-28 Published:2021-06-29
  • Contact: Bo-min SUN;;
  • Supported by:
    National Natural Science Foundation of China(81471387)


Depression is a common non-motor symptom of Parkinson′s disease (PD) and is a critical factor in the reduction of life quality of PD patients. The therapeutic effect of subthalamic nucleus deep brain stimulation (STN-DBS) on PD motor symptoms has been well documented. However, their effect on the related depression in PD is inconclusive. This article reviews the epidemiological characteristics and pathogenesis of PD and its related depression, the mechanism underlying the effects of STN-DBS on PD-related depression, the imaging and electrophysiological research of STN-DBS on PD and its related depression, the effects of STN-DBS on drug use, and the effects of electrode position on emotion.

Key words: Parkinson′s disease (PD), depression, subthalamic nucleus, deep brain stimulation

CLC Number: