Journal of Shanghai Jiao Tong University (Medical Science) ›› 2023, Vol. 43 ›› Issue (2): 208-214.doi: 10.3969/j.issn.1674-8115.2023.02.010

• Evidence-based medicine • Previous Articles    

Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysis

LIANG Yanjing1,2(), HUANG Chuxian1,3, LI Hongyan1,3, HOU Lili1,2()   

  1. 1.School of Nursing, Shanghai Jiao Tong University, Shanghai 200025, China
    2.Nursing Department, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    3.Nursing Department, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China
  • Received:2022-05-20 Accepted:2022-11-30 Online:2023-02-28 Published:2023-02-28
  • Contact: HOU Lili;
  • Supported by:
    Innovation Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20212802)


Objective ·To examine, using a systematic review and meta-analysis, the effectiveness of vitamin E on treating oral mucositis caused by radiotherapy and chemotherapy. Methods ·A systematic literature search was performed by using PubMed, Embase, Cochrane Library, Web of Science, CINAHL, OpenGrey, Chinese biomedical literature database (CBM), Chinese national knowledge infrastructure (CNKI), Wanfang Data, and China Science and Technology Journal Database (VIP). The retrieval time was up to March 2022. The risk of bias was assessed by using the Cochrane Risk-of-Bias tool, version 2.0. RevMan 5.4 was used for meta-analysis. Results ·A total of 563 literatures were retrieved. A total of 7 randomized controlled trials were included. The results of meta-analysis revealed that vitamin E supplementation did not significantly affect oral mucositis caused by chemoradiotherapy (RR=0.44, 95%CI 0.15?1.25, Z=1.54, P=0.120). However, vitamin E may have some effect on severe oral mucositis (RR=0.22, 95%CI 0.11?0.43, Z=4.33, P=0.000). Conclusion ·It cannot be explained that vitamin E can effectively treat oral mucositis caused by radiotherapy and chemotherapy, but vitamin E may be effective for severe oral mucositis.

Key words: vitamin E, oral mucositis, randomized controlled trial, meta analysis

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