Abstract:

Objective To investigate the distribution and drug resistance of pathogens in blood culture of infective endocarditis patients. Methods The isolates were tested by K--B susceptibility method with Mueller-Hinton culture medium. The results of drug susceptibility test were analyzed by WHONET 5.6 software. The distribution of pathogens in blood culture of infective endocarditis patients between 2005 and 2008 and between 2009 and 2012 was analysed. Results Thirty-nine pathogens were isolated, among which Streptococcus viridans (n=23, 59.0%) was the most common pathogen. The resistance rate of Streptococcus viridans to penicillin and ceftriaxone was 13.0%, and that to erythromycin and clindamycin was 30.4%. The resistance rate of Staphylococcus to penicillin was 81.8%, and that to oxacillin was 54.5%. The proportion of Streptococcus viridans decreased from 66.7% between 2005 and 2008 to 52.3% between 2009 and 2012, and the proportion of Staphylococcus increased from 11.1% between 2005 and 2008 to 42.9% between 2009 and 2012. The resistance rate of Streptococcus viridans to all the common antibiotics exhibited a down trend. Conclusion The monitoring of changes of distribution and drug resistance of pathogens in infective endocarditis may guide the rational application of antibiotics.

Key words: infective endocarditis, pathogen, drug resistance