Journal of Shanghai Jiao Tong University (Medical Science) ›› 2022, Vol. 42 ›› Issue (9): 1182-1187.doi: 10.3969/j.issn.1674-8115.2022.09.004

• Frontier review • Previous Articles    

Research progress and clinical intervention strategy of age-related hearing loss

HUANG Zhiwu1,2,3,4(), WU Hao1,2,3,4()   

  1. 1.Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    2.Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China
    3.Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai 200125, China
    4.Faculty of Hearing and Speech Science, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2022-05-19 Accepted:2022-07-21 Online:2022-09-28 Published:2022-09-28
  • Contact: WU Hao;
  • Supported by:
    National Natural Science Foundation of China(81730028);Clinical Research Three-year Action Plan of Shanghai Hospital Development Center(SHDC2020CR1044B);Medical-Engineering Cross Fund of Shanghai Jiao Tong University(YG2021ZD14);Project of Institute of Medical Robotics of Shanghai Jiao Tong University(XK2019015);Transformation Co-innovation Fund of Shanghai Jiao Tong University School of Medicine(TM202011)


Age-related hearing loss (ARHL), also known as presbycusis, has not been paid enough attention to worldwide due to the lack of awareness of its harmfulness for a long time. In the past decade, with the increase of aging and related social problems, ARHL has attracted more and more attention from government and society, and its pathological mechanism and clinical intervention research have also developed rapidly. However, it is still unclear about the pathogenic mechanism of ARHL caused by genetic and environmental factors. This review briefly introduces the basic pathological characteristics of ARHL, and summarizes the related researches on its genetic and environmental (especially noise exposure) pathogenic mechanism and clinical intervention effect, as well as the research progress of the writers' research group in this field, which is expected to help government promote and formulate relevant interventions and medical policies on the hearing health in the elderly.

Key words: age-related hearing loss (ARHL), presbycusis, pathogenesis, hearing intervention, cognitive impairment

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