Abstract:

Objective To investigate the correlation between the expression level of miR-93 and surgical excitability of insulin resistance (EIR) of patients with thyroid adenoma (TA). Methods The total cholesterol (TC), triglyceride (TG), fasting blood glucose (FBG), and fasting serum insulin (FINS) of 32 cases of TA combined with EIR (experiment group), 32 cases of pure TA (control group), and 30 cases of healthy people (health group) were detected by the oxidase method and the expression level of miR-93 was detected by the qRT-PCR. The results of three groups were compared. Results TC, TG, FBG, FINS, and miR-93 level of the experiment group were (6.4±0.6) mmol/L, (2.4±1.0) mmol/L, (6.3±0.5) mmol/L, (36.2±12.6) MIU/L, and 1.83±0.61; those of the control group were (6.3±0.6) mmol/L, (1.9±1.0) mmol/L, (6.0±0.5) mmol/L, (20.5±10.3) MIU/L, and 2.95±0.49; those of the health group were (5.1±0.7) mmol/L, (1.4±0.7) mmol/L, (5.1±0.6) mmol/L, (17.7±9.1) MIU/L, and 3.44±0.42, respectively. Expression levels of miR-93 of the experiment group and control group were 1.82±0.62 and 2.93±0.49 before treatment. Levels of TG, FBG, and FINS of the experiment group were higher than those of the control group (P<0.01) and health group (P<0.01). The miR-93 level of the experiment group was lower than that of the control group (P<0.01) and health group (P<0.01). The differences of the expression level of miR-93 of the experiment group and control group before and after treatment were not statistically significant (P>0.05). The expression level of miR-93 was negatively correlated with TC, TG, FBG, and FINS. Conclusion The expression of miR-93 of TA patients and TA patients with EIR is low. The expression level of miR-93 is negatively correlated with TC, TG, FBG, and FINS. The miR-93 involve in the occurrence and development of surgical EIR of patients with TA as a protective factor, rather than a pathogenic factor.

Key words: thyroid adenoma, stress resistance to insulin, microRNA, miR-93