Abstract:

Objective To observe variations of functions of islet β cells during the short-term insulin pump intensive treatment for patients with type 2 diabetes mellitus. Methods A total of 120 cases of type 2 diabetes mellitus were randomly divided into the observation group and control group with 60 cases in each group. Patients of the control group administrated oral antidiabetic drugs to control the blood glucose, while patients of the observation group were treated by the intensive insulin pump. After 4 weeks of therapy, the blood glucose, blood lipid, and relevant indicators of insulin function of two groups before and after the treatment were compared. Results After treatment, fasting blood glucose (FPG), 2 h postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and insulin resistance index (HOMA-IR) of two groups were significantly lower than those before the treatment (P<0.05), while fasting C peptide (FCP), 2 h postprandial C peptide (CP2h), high density lipoprotein cholesterol (HDL-C), and insulin secretion index (HOMA-β) were significantly higher than those before the treatment (P<0.05). After treatment, the FPG, 2hPG, HbA1c, TC, TG, and LDL-C of the observation group were all significantly lower than those of the control group (P<0.05), while the FCP, CP2h, and HDL-C were significantly higher than those of the control group (P<0.05). The HOMA-IR of the observation group was significantly lower than that of the control group (P<0.05), while the HOMA-β was significantly higher than that of the control group (P<0.05). Conclusion The short-term intensive insulin pump treatment can quickly stabilize the blood glucose level of patients with type 2 diabetes mellitus, contribute to recovering functions of islet β cells, and alleviate the insulin resistance and lipid metabolism disorder.

Key words: type 2 diabetes mellitus, insulin pump, intensive treatment, islet &beta, cells