Abstract:

Mammalian cardiogenesis involves the differentiation of pluripotent cells in the embryo towards mesoderm and cardiac cell types, including cardiomyocytes, endothelial cells, and smooth muscle cells. The cardiogenesis requires fine regulation network. Long non-coding RNA (lncRNA) is found to be one of the most important RNAs in mouse and human transcriptomes. With the development of new transcriptome sequencing techniques, researches of lncRNA have drawn more and more attention. This paper reviews crucial effects of lncRNA on the gene regulation of cardiac differentiation and development of mammals.

Key words: long non-coding RNA, gene regulation, embryo, heart development