Advances of serine starvation and p53 regulating oxidative stress of tumor cells

doi:11.3969/j.issn.1674-8115.2014.12.027

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Advances of serine starvation and p53 regulating oxidative stress of tumor cells

ZHANG Shuo, XU Bing-cong, CHEN Li-chang, WANG Fei-yang, XU Wei-rong

Laboratory for Cell and Molecular Biology, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China

Online:2014-12-28 Published:2014-12-30
Supported by:
Undergraduate Innovation Program of Shanghai Jiao Tong University School of Medicine, 2013007

Abstract

Abstract:

Fast proliferation of tumor cells is characterized by energy metabolism abnormality that the major energy supply is glycolysis. The biosynthesis of tumor cells depends on serine. Serine starvation causes oxidative stress of tumor cells and activates p53 gene, which support the survival of tumor cells. The relationship between serine starvation and p53 gene provides new ideas for the metabolic targeted treatment of tumors. This paper reviews research progresses of regulating oxidative stress of tumor cells by serine starvation and p53.

Key words: serine starvation, p53, oxidative stress

ZHANG Shuo, XU Bing-cong, CHEN Li-chang, et al. Advances of serine starvation and p53 regulating oxidative stress of tumor cells[J]. , doi: 11.3969/j.issn.1674-8115.2014.12.027.

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Advances of serine starvation and p53 regulating oxidative stress of tumor cells

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