Abstract:

Circular RNA (circRNA) is a class of covalent closed-loop non-coding RNA, existing widely in various tissue and having important biological functions. circRNA can play a regulatory role at the transcriptional or post-transcriptional level by interacting with RNA-binding proteins, regulating mRNA stability and acting as competitive endogenous RNAs. Oxidative stress, a state in which there is an imbalance between the accumulation and removal of reactive oxygen species (ROS) in the body, plays an important role in the onset and development of many diseases. Under oxidative stress conditions, numerous recent studies have shown that differentially expressed circRNA regulate the expression of inflammatory factors and apoptotic genes by acting as miRNA sponges, thereby interfering with cell survival and apoptosis. According to the regulatory effects, circRNA can participate in the damage caused by oxidative stress and play a pro-oxidative stress role. circRNA can also play an anti-oxidative stress role by upregulating antioxidant genes and reducing the effects of oxidative stress. circRNA and oxidative stress interact and induce each other, and mutually they participate in the occurrence and development of a variety of diseases. This paper reviews the relevant literature from the overview of oxidative stress, the role of circRNA under oxidative stress in different systemic diseases, and the potential mechanism of circRNA-oxidative stress interactions, aiming to provide reference for further research.

Key words: circRNA, oxidative stress, miRNA