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Research progresses in circulating microRNAs as novel biomarkers for endometrial cancer

YANG Bing-qing, TENG Yin-cheng   

  1. Department of Obstetrics and Gynecology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2016-05-28 Published:2016-05-26
  • Supported by:

    Basic Research Field Project of Science and Technology Commission of Shanghai Municipality, 13JC1404502


MicroRNAs (miRNAs) are a category of endogenous, non-coding small molecule-RNA and play a vital role in regulating gene expression by either inhibiting the translation of target genes or causing the degradation of mRNAs. Numerous studies have found that miRNAs can be released into circular peripheral blood from tumor cells and tissues and form the circulating miRNAs with high stability and high specificity, thus serving as biomarkers for the occurrence and progression of tumors. The circulating miRNA expressions in patients with endometrial cancer are different from those of healthy people and change specifically with the progression of tumors. Therefore, as novel biomarkers, circulating miRNAs have broad application prospects for the early diagnosis and prognostic evaluation of endometrial cancer.

Key words: microRNA, endometrial cancer, biomarkers