Abstract:

Gastric cancer is one of the most common digestive tract malignancies in Asia and prones to lymph node metastasis and hematogenous metastasis. Tumor remote metastasis is the main cause of death in patients with gastric cancer, while the molecular mechanism underlying the invasion and metastasis is still not fully clarified. Long non-coding RNA is a class of non-coding RNA molecules with a length of more than 200 nt and lack of open reading frames. Numerous studies have shown that long non-coding RNA plays an important role in multiple biological processes, including immune response, pluripotency of stem cells, and cell proliferation, apoptosis, and differentiation. Recent research indicated that long non-coding RNA is closely associated with invasion, metastasis, and prognosis of gastric cancer, as well as regulation of tumor invasion and metastasis through multiple pathways. This article reviews the latest research progresses of regulating the invasion and metastasis of gastric cancer by long non-coding RNA.

Key words: gastric cancer, long non-coding RNA, invasion, metastasis