Abstract: Objective · To analyze high-risk factors of infection of multidrug resistance Klebsiella pneumonia (MDR-Kpn) and difference of therapeutic effects for different treatments.  Methods · One hundred and ten MDR-Kpn strains were collected from a hospital. K-B slip diffusion method was utilized to detect the drug susceptibility of all the strains. Based on electronic medical records system, MDR-Kpn infected group included 51 patients and control group was picked out, including 51 patients as well (by1:1 ratio basing on the infected group according to the rules of under the same department, similar basic disease and all the patients in the control group isolated with the strain of Kpn). Thirty-nine clinical information of MDR-Kpn infected and control groups are collected to make single-factor analysis of high risk factors of the infection with MDR-Kpn. Multi-factor analysis was utilized between MDRKpn infected and control groups. The lasting time of different antibiotics used in MDR-Kpn infected patients were made statistics between effective and inefficacy patients.  Results · Drug susceptibility test showed that sulfonamide, phosphonomycin and amikacin, were the three most sensitive antibiotics for 110 MDR-Kpn strains. 12 clinical information, such as blood transfusion、sputum suction、invasive ventilation were all high-risk factors for the infection of MDR-Kpn (P<0.05). The lasting time during with carbapenems (P=0.025) was statistically different between effective (n=28)and noneffective group (n=23) of MDR-Kpn infection patients.  Conclusion · Controlling and eliminating high-risk factors do help to protect and decrease the infection of MDR-Kpn. Using carbapenems correctly has great influence on prognosis.

Key words:  multidrug resistance Klebsiella pneumonia, high-risk factors, drug resistance, therapeutic schemes