Abstract: Objective · To investigate the effect of acute hypervolemic fluid infusion (AHFI) during induction of general anesthesia on intraoperative hemodynamic fluctuation in the patients undergoing pancreatic robotic surgery. Methods · Sixty patients undergoing Da Vinci robot-assisted pancreatic surgery were randomly divided into routine infusion group (control group, n30) and AHFI group (n30). In AHFI group, the patients were infused with 12.5 mL/kg crystalloid solution before anesthesia induction, 12.5 mL/kg colloidal solution before pneumoperitoneum, and 8 mL/(kg·h) (crystalloid solution:colloidal solution1:1) continuously after pneumoperitoneum. The patients in control group were treated with routine liquid therapy. The mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), cardiac index (CI), stroke volume variation (SVV), and the incidence of adverse events in both groups were recorded. After operation, the exhaust time, hospitalization time and 3-month mortality of the two groups were followed up. Results · Compared with control group, the consumption of crystalloid solution, colloidal solution and both solutions in AHFI group increased (P<0.05), while the incidence of adverse events was less (P0.020). There was no significant difference in the MAP variation, HR variation and CI between the two groups (P>0.05). Compared with control group, CVP increased significantly and SVV decreased significantly in AHFI group before pneumoperitoneum, after pneumoperitoneum and after postural changes (P<0.05). There was no significant difference in the exhaust time, hospitalization time and 3-month mortality between the two groups (P>0.05). Conclusion · Compared with conventional fluid infusion, AHFI during anesthesia induction can reduce the occurrence of adverse events in the patients undergoing Da Vinci robot-assisted pancreatic surgery. There is no significant difference in the recovery of gastrointestinal function and prognosis between the two methods.

Key words: acute hypervolemic fluid infusion (AHFI), Da Vinci robot-assisted pancreatic surgery, hemodynamics, adverse event