Atmospheric fine particulate matter causing Alzheimers disease through olfactory bulb pathway: a review of recent studies

doi:10.3969/j.issn.1674-8115.2019.06.017

›› 2019, Vol. 39 ›› Issue (6): 666-.doi: 10.3969/j.issn.1674-8115.2019.06.017

• Review • Previous Articles Next Articles

Atmospheric fine particulate matter causing Alzheimers disease through olfactory bulb pathway: a review of recent studies

WANG Hao1*, JIANG Shan1*, GONG Yang-ming2, LIU Yan3, HUA Li1, DENG Xiao-bei1

1. Shanghai Jiao Tong University School of Publish Health, Shanghai 200025, China; 2. Division of Chronic and Non-communicable Diseases, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China; 3. Department of Rehabilitation, Fenglin Street Community Health Service Center, Xuhui District, Shanghai 200030, China

Online:2019-06-28 Published:2019-07-26
Supported by:
National Natural Science Foundation of China, 21777099; Shanghai Jiao Tong University Interdisciplinary Research Grant, YG2017QN71）。

Abstract

Abstract: With the improvement of quality of life, the life expectancy of residents is generally prolonged, and people suffering Alzheimer′s disease (AD) is increasing. Epidemiological and animal experiments have found that atmospheric particulate matter is associated with AD. This article briefly reviews the mechanisms of AD-related oxidative stress damage and neuroinflammation causedatmospheric fine particulate matter entering the brain via olfactory bulb pathway.

Key words: fine particulate matter (PM2.5), Alzheimer&, prime, s disease (AD), olfactory bulb, neuroinflammation, oxidative stress

CLC Number:

R749.1+6

WANG Hao1*, JIANG Shan1*, GONG Yang-ming2, LIU Yan3, HUA Li1, DENG Xiao-bei1. Atmospheric fine particulate matter causing Alzheimers disease through olfactory bulb pathway: a review of recent studies[J]. , 2019, 39(6): 666-.

[1]	YANG Le, ZHOU Yi, WANG Keyun, LAI Yali. Research on the improvement of cognitive impairment, endoplasmic reticulum stress and neuroinflammation in Alzheimer's disease by emodin [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(6): 727-734.
[2]	YU Kai, SHUAI Zhewei, HUANG Hongjun, LUO Yan. Research progress on the role and mechanisms of microglia in inflammatory diseases of central nervous system [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(5): 630-638.
[3]	WANG Liyang, XUE Wei. Research progress on the role of oxidative stress in the development of diabetic bladder dysfunction [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(2): 241-246.
[4]	WANG Xiaohong, FANG Yiru. Research progress on the neuroinflammation mechanisms in bipolar disorder [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(1): 107-112.
[5]	ZHANG Yingying, ZHANG Junyao, SONG Jiwei, WANG Shengjie, YAO Junyan. Two-sample Mendelian randomization study on the causal association between air pollution and Alzheimer′s disease [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(1): 87-94.
[6]	CHEN Minghao, LIU Peiyu, WANG Xuan, WU Yixiang, JIANG Yujin, ZHANG Chaoyang, ZHANG Jingfa. Advances in drug therapy of diabetic retinopathy [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(7): 822-829.
[7]	ZENG Dejie, CHEN Zenghui, DING Qiankun, SUN Xiaqing, SUN Qi, ZHAO Shibing. Prospect of naturally derived polysaccharides in intervention in neurodevelopmental disorders [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(6): 779-787.
[8]	JIA Junjie, XING Haifan, ZHANG Qunzi, LIU Qiye, WANG Niansong, FAN Ying. Renal protective effect and mechanism research of hypoxia inducible factor-1α inhibitor YC-1 in diabetic nephropathy mice [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(9): 1089-1098.
[9]	JIN Fangquan, FAN Chenghu, TANG Xiaodong, CHEN Yantong, QI Bingxian. Research progress in the relationship between mitochondrial dysfunction and osteoporosis [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(6): 761-767.
[10]	JIANG Xinting, HUANG Gaozhong. Research progress in the effect of nutritional intervention on cognitive impairment related to Alzheimer's disease [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(6): 788-794.
[11]	YANG Zihao, CHEN Nan, LIN Siwei. Application of digital terrain analysis to the study of cerebral cortex morphology [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(3): 342-349.
[12]	LU Ruoyu, KANG Wenhui, ZHAO Anda, LU Zhaohui, LI Shenghui. Research progress on the association between melatonin and hypertensive disorder complicating pregnancy [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(10): 1297-1303.
[13]	ZHANG Huanyu, JIANG Yiting, ZHU Xiaochen, HE Zhiyan, ZHOU Wei, SONG Zhongchen. Effects of gingipain extracts on brain neuroinflammation in mice [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(5): 570-577.
[14]	ZHANG Mi, LIU Shujun, LI Fubin, ZHANG Yan. Construction and evaluation of IgG antibody Fc combinational mutation library with mammalian cell surface display system [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(4): 510-517.
[15]	LIN Yijia, CHENG Lizhen, MIAO Ya. Research progress in the role and mechanism of abnormal mitophagy in Alzheimer's disease [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(3): 387-392.

Atmospheric fine particulate matter causing Alzheimers disease through olfactory bulb pathway: a review of recent studies

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

TrendMD

References

Related Articles 15

Recommended Articles

Metrics

Comments