›› 2020, Vol. 40 ›› Issue (3): 385-.doi: 10.3969/j.issn.1674-8115.2020.03.018

• Review • Previous Articles     Next Articles

Aberrant RNA N6-methyladenosine modification causes tumorigenesis, progression and metastasis of malignant tumorsaffecting cancer stem cells

ZHU Zheng-yang, WANG Cheng, JIANG Chen-yi, ZHAO Fu-jun   

  1. 1. Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China; 2. Clinical Medical College, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China; 3. Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China; 4. Department of Urology, Kashgar Prefecture Second People′s Hospital, Xinjiang, Kashgar 844000, China
  • Online:2020-03-28 Published:2020-04-09
  • Supported by:
    National Natural Science Foundation of China (81772746); Natural Science Foundation of Xinjiang Uygur Autonomous Region (2019D01C091).

Abstract: RNA N6-methyladenosine (m6A) modification is one of the most pervasive epigenetic modifications that correlate with gene , regulateda variety of methylases, demethylases and reader proteins. m6A has been found crucial during cancer progression, aberrant changes of which contribute to tumorigenesis and metastasis. It’s also been reported to be influential on chemotherapy and radiotherapy resistance of malignant tumorsinducing cancer stem cells (CSC) generation and enhancing post-therapy damage resistance, thus causing the progression or recurrence. In this review, we review the regulation of RNA m6A modification and focus on recent advances in functions of dysregulated m6A modification in the pathogenesis of cancer progression and recurrence. In addition, we also discuss the possible participation of CSC in this process combining current perspectives on the chemotherapy and radiotherapy resistance mechanism of CSC.

Key words: RNA methylation, N6-methyladenosine (m6A), malignant tumor, cancer stem cells, recurrence