Journal of Shanghai Jiao Tong University (Medical Science) ›› 2022, Vol. 42 ›› Issue (5): 635-645.doi: 10.3969/j.issn.1674-8115.2022.05.012

• Evidence-based medicine • Previous Articles     Next Articles

Efficacy of preventive intervention of cryotherapy on radiation-induced oral mucositis in head and neck cancer: a meta-analysis

CHEN Weihong1,2(), HOU Lili1(), YANG Ling1,2, MAO Yan3, ZHANG Jinfeng3   

  1. 1.Department of Nursing, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200023, China
    2.School of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    3.Department of Oral Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • Received:2022-02-24 Accepted:2022-05-20 Online:2022-05-28 Published:2022-05-28
  • Contact: HOU Lili;
  • Supported by:
    Yangtze River Delta Science and Technology Innovation Community Project(21002411300)

Abstract: Objective

·To systematically review the efficacy of cryotherapy in head and neck cancer patients with radiation-induced oral stomatitis.


·PubMed, EMbase, Cochrane Library, Web of Science, CNKI, WanFang, VIP and CBM databases were searched to collect randomized controlled trials (RCTs) of cryotherapy in head and neck cancer patients with ration-induced stomatitis from inception to January 31th, 2022. Literature screening, data extraction, and quality evaluation were performed independently by two researchers. Meta-analysis was then performed by using RevMan 5.4 and Stata 16.0 software.


·A total of 36 RCTs were included. The results of meta-analysis showed that compared to control group, cryotherapy group had a lower total incidence of radiation-induced stomatitis [adds ratio (OR)=0.30, 95% confidence interval (CI) 0.23?0.39, P=0.000] and a lower incidence of severe radiation-induced stomatitis (OR=0.17, 95%CI 0.14?0.21, P=0.000).


·Cryotherapy may contribute to reducing the incidence of radiation-induced stomatitis and the incidence of severe radiation-induced stomatitis.

Key words: cryotherapy, head and neck neoplasms, radiation-induced oral stomatitis, meta-analysis, randomized controlled trial

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