›› 2010, Vol. 30 ›› Issue (6): 647-.

• Monographic report (Depressive disorder) • Previous Articles     Next Articles

Research progress of roles of CREB in pathogenesis and treatment of depression

WANG Ling-xiao, reviewer；PENG Dai-hui, FANG Yi-ru, reviser   

  1. Division of Mood Disorder, Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2010-06-25 Published:2010-06-28
  • Supported by:

    Natural Science Foundation of Shanghai, 09ZR1427200; National Key Technologies R&D Program of“10th Five-Year Plan”, 2004BA720A21-02；National High-Tech Research and Development Program of China, “863” Program, 2006AA02Z430

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Abstract:

The transcription factor cAMP response element-binding protein (CREB) has been implicated in relevant for pathogenesis and therapy of depression in many studies. CREB is involved in the molecular and cellular mechanism of chronic antidepressant treatment, and serves as a convergence point for multiple classes of antidepressant drugs. CREB is upregulated and activated in the hippocampus by treatment with chronic antidepressants. Increasing CREB levels in the hippocampus of rodent models results in antidepressive effects. However, increasing CREB levels in some other brain regions leads to depression-like behaviors. In this article, the roles of CREB in the pathogenesis of depression and in mediating effects of antidepressant treatment are reviewed.

Key words: cAMP response element-binding protein, depression, antidepressants