Abstract:

Objective To observe and compare the oxidative stress in patients with chronic kidney diseases (CKD) of different clinical stages. Methods One hundred and sixty-three patients with CKD were enrolled, and CKD1 to CKD5 groups were divided according to estimated glomerular filtration rate (eGFR). Besides, patients in CKD5 group were subdivided into CKD5-hemodialysis group and CKD5-non-hemodialysis group according to dialysis management. Serum malonaldehyde (MDA) level and superoxide dismutase (SOD) activity were detected in each group, and statistical analysis was conducted. Results Serum MDA level and SOD activity had linear correlation with eGFR （R2=0.547，R2=0.406；P<0.05）. For CKD2 group, CKD3 group and CKD4 group, serum MDA level was highest in CKD4 group and lowest in CKD2 group （P<0.05）, and SOD activity was lowest in CKD4 group and highest in CKD2 group (P<0.05）. However, there was no significant difference in these two parameters between CKD4 group and CKD5 group and between CKD2 group and CKD1 group （P>0.05）. There were significant differences in serum MDA levels and SOD activity between CKD5-hemodialysis group and CKD5-non-hemodialysis group [（9.20±1.75）nmol/mL vs (7.01±1.40) nmol/mL and （59.24±17.82）U/mL vs （72.21±17.82）U/mL, respectively （P<0.05）]. Conclusion Oxidative stress increases with renal function decrease in patients with CKD. Compared with CKD5 patients without hemodialysis, those managed with hemodialysis have more severe oxidative stress.

Key words: chronic kidney disease, oxidative stress, malonaldehyde, superoxide dismutase