Abstract:

Objective To explore the correlation of early trauma experience with depression and bipolar disorder. Methods Three hundred and seventeen patients with depression and 124 patients with bipolar disorder were enrolled. The general data of patients were collected by self-made questionnaire, including gender, age, education experience, age at first episode, family history of mental diseases, disease duration, number of attack, working status and family status. Early trauma experience was assessed with early trauma experience inventory-short form, which involved four dimensions of common trauma, body trauma, emotional abuse and sexual abuse, and the scores of patients with depression and bipolar disorder were compared with nonparametric test. The correlation of different kinds of early trauma experience with depression and bipolar disorder was explored by Logistic regression analysis. Results The incidence of common trauma experience and total score of inventory in patients with bipolar disorder were significantly higher than those in patients with depression (P<0.05). In patients with depression, common trauma was related to family status （P<0.001）, body trauma was significantly related to gender, family status and working status （P＜0.05）, and emotional abuse was related to family status and number of attack （P<0.05）. In patients with bipolar disorder, common trauma was significantly related to family status and family history of metal diseases （P<0.05）, emotional abuse was significantly related to family status （P<0.01）, and sexual abuse was related to gender （P<0.01）. Conclusion Early trauma experience is correlated with both depression and bipolar disorder, and different kinds of trauma may play different roles in the onset and development of these two diseases.

Key words: early trauma, depression, bipolar disorder