›› 2011, Vol. 31 ›› Issue (11): 1518-.doi: 10.3969/j.issn.1674-8115.2011.11.003

• Monographic report (Bipolar disorder) • Previous Articles     Next Articles

Association of 5HTTLPR gene polymorphisms with bipolar disorder and affective temperaments

YUAN Cheng-mei1, YU Shun-ying2, LI Ze-zhi1, HUANG Jia1, HONG Wu1, QIAN Yi-ping2, FANG Yi-ru1   

  1. 1.Department of Mood Disorder, 2.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    National Natural Science Foundation of China, 30270494；National High Technology Research and Development Program of China, “863” Program, 2006AA02Z430；National Key Technology Research and Development Program of China in “Tenth-Five Year Plan”, 2004BA720A21-02；Shanghai Municipal Health Bureau Foundation, 08GWQ075, 2007Y14；Shanghai Jiaotong University School of Medicine Foundation, 2008-6

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Abstract:

Objective To explore the association of serotonin transporter gene-linked polymorphic region (5-HTTLPR) gene polymorphisms with bipolar disorder and affective temperaments. Methods Case-control design was adopted, and 305 patients with bipolar disorder and 272 normal controls were enrolled. Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A) was employed to assess the affective temperaments. Chi-square test, T test, nonparametric test and ANOVA were used to explore the association of 5-HTTLPR gene polymorphisms with bipolar disorder and affective temperaments. Results 5-HTTLPR L/S polymorphisms were associated with bipolar disorder in females (genotype, χ2=6.769, P=0.034；allele, χ2=6.028, P=0.014）, S allele of 5-HTTLPR L/S polymorphisms was associated with anxious temperament of patients with bipolar disorder （t=8.248，P=0.005）, and LA allele of 5-HTTLPR rs25531 A/G polymorphisms was associated with hyperthymic temperament of patients with bipolar disorder （Z=-2.205，P=0.027）. Conclusion 5-HTTLPR gene polymorphisms are associated with the prevalence of bipolar disorder in females, which can also regulate the affective temperaments of patients with bipolar disorder in some degree.

Key words: bipolar disorder, serotonin transporter gene-linked polymorphic region, gene polymorphism, affective temperament, Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version