Research progress of microRNA and renal fibrosis

doi:10.3969/j.issn.1674-8115.2011.12.029

›› 2011, Vol. 31 ›› Issue (12): 1786-.doi: 10.3969/j.issn.1674-8115.2011.12.029

• Review • Previous Articles Next Articles

Research progress of microRNA and renal fibrosis

LIU Jian, WANG Wei-ming

Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

Online:2011-12-28 Published:2012-01-04

Abstract

Abstract:

microRNA (miRNA), consisted of about 22 nucleotides, are noncoding small RNA. They can impact the target RNA, thus regulating the physiological and pathological processes and possessing an significant action in cell proliferation, apoptosis, and differentiation. It has been reported that miRNA, modulating the deposition of collagen, expression of fibronectin, epithelial-to-mesenchymal transition and effect of transforming growth factor-β in kidney, are involved in the mechanism of renal fibrosis.

Key words: microRNA, fibrosis, renal

LIU Jian, WANG Wei-ming. Research progress of microRNA and renal fibrosis[J]. , 2011, 31(12): 1786-.

[1]	Qian Yile, Yao Sai, Chen Sifeng, Li Quanfu, Zhao Meng. Research progress on the molecular mechanisms and targeted interventions of macrophage-mediated myocardial fibrosis [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(3): 348-357.
[2]	Xu Rui, Guo Jiacheng, Xie Shiyao, Han Deheng, Yue Xiuqin. Research advances in nanomaterials in cardiac fibrosis repair: from precision therapy to tissue remodeling [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(3): 377-384.
[3]	Zhang Xianjing, Chen Suzhen. Mechanisms and therapeutic progress of Chinese materia medica in the prevention and treatment of renal fibrosis in diabetic nephropathy [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(1): 90-99.
[4]	HE Jiayin, CHEN Siyuan, SHI Qing, ZHANG Muchen, YI Hongmei, DONG Lei, QIAN Ying, WANG Li, CHENG Shu, XU Pengpeng, ZHAO Weili. Clinicopathologic characteristics, gene mutation profile, and prognostic analysis of patients with adrenal diffuse large B-cell lymphoma [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(9): 1194-1201.
[5]	HE Chen, YAN Silei, ZHOU Weitao, LING yong, YU Ningning, JIANG Kun, QIAN Liling. Clinical analysis and literature integration study of cystic fibrosis complicated by allergic bronchopulmonary aspergillosis [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(8): 1066-1073.
[6]	HE Suhui, ZHAO Yinlong, CHANG Alex Chia Yu. Effects of telomerase gene therapy on pressure overload-induced heart failure in mice [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(8): 949-956.
[7]	CHEN Zixuan, LIU Min. Research progress on immune cell therapy in renal cell carcinoma [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(7): 916-925.
[8]	GU Liangrui, YAN Bicong, FANG Tonglei, WU Jinliang. Correlation between brain imaging features and cognitive impairment in end-stage renal disease patients based on susceptibility-weighted imaging [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(6): 760-765.
[9]	ZHAI Wenhui, HUANG Qifang, CHEN Yilin, LI Xiaodong, WANG Jiguang. Serum osteoglycin level in relation to renal function and blood pressure in non-diabetic patients with hypertension [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(5): 578-584.
[10]	WANG Renjie, ZHU Chaoyu, FANG Yunyun, XIAO Yuanyuan, WANG Qianqian, SONG Wenjing, WEI Li. Effects and mechanisms of liraglutide in ameliorating liver fibrosis in NAFLD mice [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(4): 415-425.
[11]	ZHANG Xinxin, YAN Chonghuai. Advances in epigenetic mechanisms of lead toxicity [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(4): 500-507.
[12]	LIU Xiaoli, CAO Li. Advances in the treatment of adrenoleukodystrophy [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(1): 95-100.
[13]	WU Wangshu, WANG Minzhou, SONG Ahui, ZHAO Bingru, LU Jiayue, HONG Wenkai, GU Leyi, XIE Kewei, LU Renhua. Efficacy and safety of compound amino acid capsules in the treatment of malnutrition and calcium and phosphorus metabolism disorders in maintenance hemodialysis patients [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(8): 1023-1029.
[14]	JI Xueli, GOU Jinyu, CHEN Suyun, FU Hongliang, ZOU Renjian, WANG Hui. Clinical predictive value of 20-minute residual rate of diuretic renal scintigraphy in the timing of pyeloplasty [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(7): 899-906.
[15]	WANG Wenji, ZHONG Kaiyi, LI Jiaolun, ZHOU Yueling, HUANG Tao, DUAN Lizhu, SHEN Yuqi, LI Xuezhu, DING Feng, XIE Danshu. Association between urinary excretion of protein-bound uremic toxins and upper urinary tract calculus [J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(5): 591-598.

Research progress of microRNA and renal fibrosis

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

TrendMD

References

Related Articles 15

Recommended Articles

Metrics

Comments