›› 2011, Vol. 31 ›› Issue (12): 1786-.doi: 10.3969/j.issn.1674-8115.2011.12.029

• Review • Previous Articles     Next Articles

Research progress of microRNA and renal fibrosis

LIU Jian, WANG Wei-ming   

  1. Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2011-12-28 Published:2012-01-04


microRNA (miRNA), consisted of about 22 nucleotides, are noncoding small RNA. They can impact the target RNA, thus regulating the physiological and pathological processes and possessing an significant action in cell proliferation, apoptosis, and differentiation. It has been reported that miRNA, modulating the deposition of collagen, expression of fibronectin, epithelial-to-mesenchymal transition and effect of transforming growth factor-β in kidney, are involved in the mechanism of renal fibrosis.

Key words: microRNA, fibrosis, renal