Abstract:

Objective To investigate the role of different serum lipid parameters in prediction of hypertension in mid-aged and young people in Chongqing. Methods The data of 20 000 subjects undergoing health examinations in Health Examination Center of the First Affiliated Hospital of Chongqing Medical University in 2009 were collected. The correlation of triglyceride (TG), serum total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and non-high-density lipoprotein-cholesterol (Non-HDL-C) with systolic blood pressure (SBP) and diastolic blood pressure (DBP) was explored, and the relationship among different serum lipid parameters were analysed. Serum lipid parameters with strong correlation with blood pressure were selected, and role of these parameters and their different combinations in prediction of area under receiver operator characteristic (ROC) curve of subjects with hypertension was analysed. Results Health examinations revealed that three were 3 102 patients with hypertension, and the prevalence was 15.51%. Among these patients, there were 2 294 males and 808 females, and the prevalence of males was significantly higher than that of females (20.43% vs 9.21%，P<0.05). After adjustment for age and sex of patients with hypertension, TC/HDL-C had the strongest correlation with blood pressure, followed by LDL-C/HDL-C and Non-HDL-C. TC/HDL-C had strong correlation with LDL-C/HDL-C, Non-HDL-C, HDL-C, TG, LDL-C and TC (r=0.926, 0.784, -0.753, 0.724, 0.715 and 0.642 respectively; P<0.001 for all). All the areas under ROC curve of hypertension predicted by TC/HDL-C, LDL-C/HDL-C, Non-HDL-C, TG and their different combinations were >0.5, and the area under ROC curve predicted by TC/HDL-C was the largest. For the same serum lipid parameter and its combinations, areas under ROC curve of females were significantly larger than those of males (P<0.05). Conclusion C/HDL-C may be the optimal serum lipid parameter in prediction of hypertension in Chongqing mid-aged and young people, especially for females.

Key words: hypertension, serum lipid parameter, total cholesterol to high-density lipoprotein-cholesterol ratio, ROC curve