Abstract:

Objective To investigate the association of interleukin-6 (IL-6) and angiopoietin receptor Tie2 in dialysate with high peritoneal solute transport in patients undergoing peritoneal dialysis. Methods Sixty patients undergoing stable continuous ambulatory peritoneal dialysis (CAPD) were included, and were divided into two groups according to the values of dialysis/plasma creatinine (D/Pcr) at 4 h in peritoneal equilibration test. D/Pcr was <0.65 in L/A group (n=39), while that was ≥0.65 in H/A group (n=21). The mass concentrations of IL-6 and Tie-2 in dialysate of two groups were measured by ELISA, and the association of IL-6 and Tie-2 with D/Pcr was explored. Results The mass concentrations of IL-6 and Tie-2 in dialysate of H/A group were (21.71±8.88) pg/mL and (1.23±0.43) ng/mL respectively, and were significantly higher than those of L/A group, which were (13.94±5.43) pg/mL and (0.95±0.43) ng/mL respectively (P<0.05). Univariate correlation analysis indicated that both IL-6 and Tie-2 in dialysate were positively related to D/Pcr (r=0.366, P=0.004; r=0.402, P=0.001), and multiple stepwise regression analysis revealed that IL-6 and Tie-2 in dialysate were independent risk factors for D/Pcr （β=0.007， P=0.026； β=0.162， P=0.006）. Conclusion Significant abdominal inflammation and angiogenesis may exist in patients undergoing CAPD with high peritoneal solute transport status. IL-6 and Tie-2 in dialysate are independent risk factors for peritoneal permeability, which indicates abdominal inflammation and angiogenesis may be related to the change of peritoneal permeability.

Key words: interleukin-6, Tie-2, angiogenesis, high peritoneal solute transport rate, peritoneal dialysis