›› 2013, Vol. 33 ›› Issue (3): 354-.doi: 10.3969/j.issn.1674-8115.2013.03.020

• Review • Previous Articles     Next Articles

Research progress of relationship between mutations of insulin gene and diabetes mellitus

LI Can1,2, LIU Li-mei1   

  1. 1.Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, the Sixth People´s Hospital, Shanghai Jiaotong University, Shanghai 200233, China； 2.Suzhou University, Suzhou 215006, China
  • Online:2013-03-28 Published:2013-03-29
  • Supported by:

    National Natural Science Foundation of China, 81270876, 30771022, 30971384； Shanghai Science and Technology Committee Foundation, 10XD1403400

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Abstract:

Insulin is the unique hypoglycemic hormone which is secreted by islet β-cells. Insulin gene mutations could result in insulinopathies, permanent neonatal diabetes mellitus (PNDM), maturity onset diabetes of the young (MODY) and auto-antibodies-negative type 1 diabetes mellitus. The research progress of relationship between mutations of insulin gene and diabetes mellitus is reviewed in this article.

Key words: insulin gene, mutation, diabetes mellitus