›› 2011, Vol. 31 ›› Issue (1): 99-.doi: 10.3969/j.issn.1674-8115.2011.01.023

• 综述 • 上一篇    下一篇


闫玉梅1, 梅 举2, 孙 锟1, 丁芳宝2   

  1. 1.上海交通大学 医学院附属上海儿童医学中心心内科, 上海 200127;2.上海交通大学 医学院附属新华医院心胸外科, 上海 200092
  • 出版日期:2011-01-28 发布日期:2011-02-01
  • 通讯作者: 梅 举, 电子信箱: ju_mei@sohu.com。
  • 作者简介:闫玉梅(1984—), 女, 博士生;电子信箱: yanyumei_020601@163.com。
  • 基金资助:


Research progress of aquaporin-1 and its role in heart

YAN Yu-mei1, MEI Ju2, SUN Kun1, DING Fang-bao2   

  1. 1.Department of Cardiology, Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China;2.Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2011-01-28 Published:2011-02-01
  • Supported by:

    National Natural Science Foundation of China, 30872558



关键词: 水通道蛋白, 心肌水肿, 调节, 体外循环


Aquaporin-1 (AQP1), which has a special molecular structure and is regulated by many factors, is the earliest found and most widely distributed aquaporin (AQP). In addition to transporting water, AQP1 may participate in a variety of gas transportation and be involved in cell metastasis process. In heart tissues, AQP1 is mainly expressed in erythrocytes, capillary endothelial cells and myocardial cells. AQP1 is located in cytoplasma membrane of myocardial cells, and may participate in the process of excitation-contraction coupling and transportation of water, which regulates water metabolism in various physiological and pathological process. Cardiac surgery with extracorporeal circulation can influence the expression and activity of AQPs, leading to cardiac edema. The investigations of AQPs have important guiding effects in clinical practice.

Key words: aquaporin, myocardial edema, regulation, cardiopulmonary bypass