›› 2011, Vol. 31 ›› Issue (12): 1786-.doi: 10.3969/j.issn.1674-8115.2011.12.029

• 综述 • 上一篇    下一篇


刘 剑, 王伟铭   

  1. 上海交通大学 医学院附属瑞金医院肾脏科, 上海 200025
  • 出版日期:2011-12-28 发布日期:2012-01-04
  • 通讯作者: 王伟铭, 电子信箱: wweiming@medmail.com.cn。
  • 作者简介:刘 剑(1987—), 男, 硕士生;电子信箱: jim_liu@yeah.net。

Research progress of microRNA and renal fibrosis

LIU Jian, WANG Wei-ming   

  1. Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2011-12-28 Published:2012-01-04



关键词: 微小RNA, 纤维化, 肾脏


microRNA (miRNA), consisted of about 22 nucleotides, are noncoding small RNA. They can impact the target RNA, thus regulating the physiological and pathological processes and possessing an significant action in cell proliferation, apoptosis, and differentiation. It has been reported that miRNA, modulating the deposition of collagen, expression of fibronectin, epithelial-to-mesenchymal transition and effect of transforming growth factor-β in kidney, are involved in the mechanism of renal fibrosis.

Key words: microRNA, fibrosis, renal