›› 2012, Vol. 32 ›› Issue (11): 1512-.doi: 10.3969/j.issn.1674-8115.2012.11.024

• 综述 • 上一篇    下一篇


潘 昱, 张一帆   

  1. 上海交通大学 医学院附属瑞金医院核医学科, 上海 200025
  • 出版日期:2012-11-28 发布日期:2012-11-30
  • 通讯作者: 张一帆, 电子信箱: zhangyifan1992@yahoo.com.cn。
  • 作者简介:潘 昱(1987—), 男, 硕士生;电子信箱: dimi_luki@163.com。
  • 基金资助:

    国家自然科学基金(81171367) ;上海市教委科研创新项目(12YZ041)

Application of radionuclide reporter gene imaging in therapeutic gene monitoring

PAN Yu, ZHANG Yi-fan   

  1. Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2012-11-28 Published:2012-11-30
  • Supported by:

    National Natural Science Foundation of China, 81171367;Innovation Program of Shanghai Education Committee, 12YZ041



关键词: 报告基因, 放射性核素显像, 基因治疗, 分子影像


As a new disease therapy method, gene therapy shows a broad application prospect. However, there are still lots of problems in gene therapy to be solved. To evaluate the efficiency of gene therapy, it is requisite to monitor and evaluate the localization and expression of the therapeutic gene in vivo. Radionuclide reporter gene imaging, with rapid development in recent years, is considered as a non-invasive and sensitive method in monitoring the expression of the therapeutic gene in vivo. This method, which has the advantage of high sensitivity and specificity and may carry on deep-tissue imaging and repeat imaging, has shown a good application prospect. The mechanism, characteristics and value of radionuclide reporter gene imaging in monitoring gene therapy are reviewed in this paper.

Key words: reporter gene, radionuclide imaging, gene therapy, molecular imaging