上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

279株泌尿生殖道分离解脲脲原体的药敏分析

肖淑珍1，韩立中1，王文奎2   

  1. 上海交通大学 医学院附属瑞金医院 1.临床微生物科， 2.烧伤科， 上海 200025
  • 出版日期:2016-04-28 发布日期:2016-05-26
  • 通讯作者: 王文奎, 电子信箱: wenkuiwang@hotmail.com。
  • 作者简介:肖淑珍（1988—）， 女， 硕士生; 电子信箱: zndxxsz@163.com。

Drug susceptibility analysis of 279 Ureaplasma urealyticum strains isolated from genitourinary tract

XIAO Shu-zhen1, HAN Li-zhong1, WANG Wen-kui2   

  1. 1.Department of Clinical Microbiology, 2.Department of Burns, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2016-04-28 Published:2016-05-26

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摘要：

目的 了解支原体感染情况及对常见抗菌药物的耐药状况，为指导临床合理用药提供依据。方法 使用支原体培养、鉴定及药敏试剂盒，对临床收集的2 639例疑似泌尿生殖道感染患者的标本进行支原体的检测、鉴定及药敏试验。结果 在2 639份标本中，支原体阳性333份，阳性率为12.6%。其中解脲脲原体单一阳性279份，占83.8%；人型支原体单一阳性23例，占6.9%；解脲脲原体和人型支原体混合阳性31例，占9.3%。女性患者支原体检出率（15.0%）高于男性患者（4.3%）。其中，31~40岁女性患者支原体培养阳性率高于其他年龄段患者，阳性率为23.6%。解脲脲原体对抗菌药物的敏感率依次为交沙霉素（98.6%）、美满霉素（96.4%）、多西环素（96.1%）、四环素（97.4%）和克拉霉素（87.1%）；耐药率较高的是环丙沙星（80.2%）、司巴沙星（31.5%）和红霉素（26.2%）。结论 泌尿生殖道支原体感染主要由解脲脲原体引起，临床上需对疑似支原体感染患者进行支原体的培养和药敏试验，经验治疗时建议选择交沙霉素、多西环素或美满霉素。

关键词: 支原体, 泌尿生殖道, 耐药性

Abstract:

Objective To investigate mycoplasma infection and its resistance to common antimicrobial agents and provide evidence for guiding clinical rational drug use. Methods A total of 2 639 samples from patients suspected of genitourinary tract infection were collected. Mycoplasma culture, identification, and drug sensitivity kit were used to perform mycoplasma detection, identification, and drug sensitivity tests. Results Three hundred and thirty-three of 2 639 samples were mycoplasma-positive and the positive rate was 12.6%. Two hundred and seventy-nine (83.8%) of these 333 samples were only Ureaplasma urealyticum (Uu)-positive, 23 (6.9%) were only Mycoplasma hominis (Mh)-positive, and 31 (9.3%) were Uu and Mh-positive. The detection rate in female patients (15.0%) was higher than that in male patients (4.3%). Mycoplasma-positive rate in 31-40-year-old female patients (23.6%) was higher than that in patients of other age groups. Antibiotic susceptibility rates of Uu to josamycin, minocycline, doxycycline, tetracycline, clarithromycin, ciprofloxacin, sparfloxacin, and erythromycin were 98.6%, 96.4%, 96.1%, 97.4%, 87.1%, 80.2%, 31.5%, and 26.2%, respectively. Conclusion Mycoplasma genitourinary tract infection is mainly caused by Uu. It is necessary to perform mycoplasma culture and drug sensitivity test for patients suspected of mycoplasma infection. Josamycin, doxycycline, and minocycline are recommended for empirical treatment.

Key words: mycoplasma, urogenital tract, antimicrobial resistance