上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 综述 • 上一篇    下一篇

BAP1及其抑癌作用研究新进展

李则，任尊，涂鸿鹄，简政，余健秀，邓蓉   

  1. 上海交通大学 基础医学院，上海 200025
  • 出版日期:2017-05-28 发布日期:2017-05-31
  • 通讯作者: 邓蓉，电子信箱：dr_dengrong@163.com。
  • 作者简介:李则（1996—），男，本科生；电子信箱：ah627387599@sjtu.edu.cn。
  • 基金资助:

    中国博士后科学基金（2016M600323）

Research advance on BAP1 and its function in tumor suppression

LI Ze, REN Zun, TU Hong-hu, JIAN Zheng, YU Jian-xiu, DENG Rong   

  1. Basic medical college of Shanghai Jiao Tong University, Shanghai 200025, China
  • Online:2017-05-28 Published:2017-05-31
  • Supported by:

    China Postdoctoral Science Foundation，2016M600323

PDF (PC)

1090

摘要：

BAP1是泛素羧基末端水解酶家族中的一员，其基本功能是去除底物蛋白质的泛素化修饰。BAP1还是多种细胞功能调控的关键分子，通过依赖或不依赖其去泛素化功能，调节基因表达、细胞周期、细胞分化、细胞凋亡和DNA损伤应答等。由于BAP1在细胞内的重要作用，其基因突变或表达水平的下调能够显著提高多种肿瘤的易患性，但具体的致病机制目前尚不清楚，有待进一步的研究，这也为未来肿瘤治疗带来新的契机。

关键词: BAP1, 去泛素化, 肿瘤

Abstract:

BAP1 is a member of the ubiquitin C-terminal hydrolases (UCH) subfamily of deubiquitylases with basic function of removing monoubiquitin or ubiquitin chains from the specific substrate proteins. As well, it is a key factor in regulating gene expression, cell cycle, cell differentiation, cell apoptosis and DNA damage response, dependent or independent of its deubiquitination function. Evidences have revealed that mutation or down-regulation of BAP1 can prominently increase the occurrence of cancers, including uveal melanoma, mesothelioma, renal cell carcinoma, breast cancer and lung cancer. Currently, the tumor spectrum and the pathogenic mechanism on BAP1 have not been illustrated clearly, and need to be further researched, which might bring a new opportunity in treatment of cancers.

Key words: BAP1, deubiquitination, cancer