上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (5): 552-.doi: 10.3969/j.issn.1674-8115.2018.05.014

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小胶质细胞和外周血单核细胞在心境障碍中的作用

毛睿智 1, 2，张晨 1, 2，方贻儒 1, 2   

  1. 上海交通大学医学院附属精神卫生中心 1.心境障碍科，2.生化实验室，上海 200030
  • 出版日期:2018-05-28 发布日期:2018-05-28
  • 通讯作者: 方贻儒，电子信箱：yirufang@aliyun.com。
  • 作者简介:毛睿智（1988—），女，博士生；电子信箱： maomaoaofei@163.com。
  • 基金资助:
    “十二五”国家科技支撑项目（2012BAI01B04）；“十三五”国家重点研发计划（2016YFC1307100）；国家自然科学基金（91232719，81771465）；国家临床重点专科 -上海市精神卫生中心（卫生部医政司 2011-873）；上海市精神疾病临床医学中心（2014）

Research progress of microglia and peripheral monocytes in mood disorders

MAO Rui-zhi1, 2, ZHANG Chen1, 2, FANG Yi-ru1, 2   

  1. 1. Division of Mood Disorder; 2. Biochemical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2018-05-28 Published:2018-05-28
  • Supported by:
    “12th Five-year Plan”of National Key Technologies R&D Program, 2012BAI01B04;“13th Five-year Plan”of National Key R&D Program, 2016YFC1307100; National Natural Science Foundation of China, 91232719, 81771465; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873; Shanghai Clinical Center for Mental Disorders, 2014

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摘要： 炎症在心境障碍发病中的作用引起了学术界的关注。小胶质细胞和外周血单核细胞作为中枢和外周免疫的代表性细胞在心境障碍患者中均表现为异常活化，并释放相应的细胞因子。 2种免疫细胞分别在遗传表达和功能等方面存在共性，探索两者在免疫通路中如何对情绪、行为等产生影响，对于理解心境障碍的发病机制和研发潜在的药物均具有重要作用。

关键词: 小胶质细胞, 外周血单核细胞, 心境障碍, 炎症, 抑郁症, 双相情感障碍

Abstract:

The role of inflammation in the pathomechanism and treatment of mood disorders has drawn public attention in the field. As representatives of central and peripheral immune systems, microglia and peripheral monocytic cells become more active and release relative cytokines in mood disorders patients. These two classes of immune cells have similar genetic and functions. It is beneficial to explore how microglia and monocytes influence emotion and behavior via immune signaling pathway for understanding the disease pathogenesis and developing potential therapeutic strategies.

Key words: microglia, peripheral monocyte, mood disorders, inflammation, major depressive disorder, bipolar disorder

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