上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2020, Vol. 40 ›› Issue (2): 200-.doi: 10.3969/j.issn.1674-8115.2020.02.009

• 论著·临床研究 • 上一篇    下一篇

托吡酯改善非典型抗精神病药所致体质量增加的meta分析

王丹丹，汪也微，方新宇，陈 艳，余玲芳，张 晨   

  1. 上海交通大学医学院附属精神卫生中心生化研究室，上海 200030
  • 出版日期:2020-02-28 发布日期:2020-03-20
  • 通讯作者: 张 晨，电子信箱：zhangchen645@gmail.com。
  • 作者简介:王丹丹（1994—），女，硕士生；电子信箱：wangdan_630@163.com。
  • 基金资助:
    国家重点研发计划（2018YFC1314302）；国家自然科学基金（81771450，81471358）；上海市科学技术委员会西医引导类项目（14411969000）；上海市卫生和计划生育委员会科研项目（201540029）。

Meta-analysis of topiramate to improve body weight increase causedatypical antipsychotic drugs

WANG Dan-dan, WANG Ye-wei, FANG Xin-yu, CHEN Yan, YU Ling-fang, ZHANG Chen   

  1. Department of Biochemistry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-02-28 Published:2020-03-20
  • Supported by:
    National Key R&D Program of China (2018YFC1314302); National Natural Science Foundation of China (81771450, 81471358); Western Medicine Guide Project of Shanghai Municipal Science and Technology Commission (14411969000); Foundation of Shanghai Municipal Commission of Health and Family Planning (201540029).

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摘要： 目的·系统评价托吡酯减轻非典型抗精神病药所致体质量增加的作用。方法·计算机检索中国知网、万方数据库、中国生物医学文献服务系统、Cochrane Library 以及PubMed、Embase、PsycINFO数据库，检索文献起始时间不限、截止时间为2019年3月。收集关于托吡酯减轻非典型抗精神病药关联的体质量增加的随机对照试验。由2名研究者独立进行文献筛选、资料提取和文献质量评价后，采用RevMan 5.3软件进行meta分析。结果·最终纳入20篇随机对照研究，共有1 024例患者。Meta分析结果显示：托吡酯能够有效改善非典型抗精神病药所致的体质量增加，其差异有统计学意义[加权均数差（weighted mean difference, WMD） -4.09, 95% CI -5.74～-2.44，P0.000]；体质量指数（body mass index，BMI）也有明显的改善（WMD-2.42, 95% CI -3.02～-1.82，P0.000）。结论·托吡酯能有效改善非典型抗精神病药所引起的体质量增加及BMI的增加。

关键词: 托吡酯, 非典型抗精神病药, 体质量, 体质量指数

Abstract:

Objective · To systematically evaluate the effect of topiramate on reducing body weight increase causedatypical antipsychotic drugs. Methods · A literature search was performedusing PubMed database, Embase database, PsycINFO database, Cochrane Library, CNKI, WanFang data and SinoMed. Randomized placebo-controlled trials of topiramate targeting weight-gain causedatypical antipsychotic drugs inception to Mar. 2019. Two researchers independently screened literatures according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality of included studies. The meta-analysis was performed using RevMan 5.3 software. Results · A total of 20 randomized controlled trials were included, consisting of 1 024 subjects. The results of meta-analysis showed that topiramate was significant effective in reducing atypical antipsychotic-related weight gain [weighted mean difference (WMD)-4.09, 95% CI -5.74 - -2.44, P0.000]. The body mass index (BMI) was also improved significantly (WMD-2.42, 95% CI -3.02 - -1.82, P0.000). Conclusion · Topiramate can effectively improve the body weight and BMI increase causedatypical antipsychotic drugs.

Key words: topiramate, atypical antipsychotic drug, body weight, body mass index (BMI)