纳米材料通过降低活性氧水平促进骨组织再生的研究进展

doi:10.3969/j.issn.1674-8115.2025.04.011

上海交通大学学报（医学版） ›› 2025, Vol. 45 ›› Issue (4): 487-492.doi: 10.3969/j.issn.1674-8115.2025.04.011

纳米材料通过降低活性氧水平促进骨组织再生的研究进展

鲁佳艺¹^,², 刘锦喆¹^,², 郭尚春¹^,³^,⁴, 陶诗聪¹^,³()

^1.上海交通大学医学院附属第六人民医院临床医学院，上海 200233
^2.上海交通大学医学院，上海 200025
^3.上海交通大学医学院附属第六人民医院骨科，上海 200233
^4.上海市四肢显微外科研究所，上海 200233

收稿日期:2024-10-10 接受日期:2024-12-10 出版日期:2025-04-28 发布日期:2025-04-21
通讯作者: 陶诗聪 E-mail:sctao@shsmu.edu.cn
作者简介:鲁佳艺（2002—），女，本科生；电子信箱：lujiayi1101@sjtu.edu.cn
刘锦喆（2003—），男，本科生；电子信箱：2287630083@qq.com。
第一联系人：鲁佳艺、刘锦喆为共同第一作者
基金资助:
国家自然科学基金(81802226);上海市浦江人才计划(2019PJD038);2020年上海市“医苑新星”青年医学人才培养资助计划;上海交通大学医学院“双百人”项目(2022-017);上海市第六人民医院优秀人才培育项目(ynyq202101)

Advances in nanomaterials for promoting bone tissue regeneration by reducing reactive oxygen species levels

LU Jiayi¹^,², LIU Jinzhe¹^,², GUO Shangchun¹^,³^,⁴, TAO Shicong¹^,³()

^1.Clinical Medical College of Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
^2.Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
^3.Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
^4.Shanghai Institute of Microsurgery on Extremities, Shanghai 200233, China

Received:2024-10-10 Accepted:2024-12-10 Online:2025-04-28 Published:2025-04-21
Contact: TAO Shicong E-mail:sctao@shsmu.edu.cn
Supported by:
National Natural Science Foundation of China(81802226);Program of Pujiang Talents of Shanghai(2019PJD038);Shanghai "Rising Stars of Medical Talent" Youth Development Program in 2020;"Two-hundred Talents" Program of Shanghai Jiao Tong University School of Medicine(2022-017);Shanghai Sixth People's Hospital Excellent Young Scientist Development Program(ynyq202101)

摘要/Abstract

摘要：

活性氧（reactive oxygen species，ROS）是骨组织受损伤后常见的产物。如果ROS不能被及时清除，可在细胞内引发氧化应激，从而对骨组织的再生产生负面影响。近年来，随着研究的深入，能够降低ROS水平的纳米材料在促进骨组织再生方面的作用日益凸显。目前用于降低ROS水平的纳米材料，主要包括经表面修饰和微结构设计的纳米材料、掺杂改性无机材料的纳米材料、功能化聚合物材料及水凝胶、纳米酶材料。但这些纳米材料在临床应用时仍然存在一定局限性，主要原因是其可能具有细胞毒性，且缺乏足够的临床试验数据。该文对利用纳米材料降低ROS水平以促进骨再生的研究进行总结，为未来设计和开发促进骨组织再生的新型纳米材料提供思路。

关键词: 纳米材料, 活性氧, 骨再生, 抗氧化

Abstract:

Reactive oxygen species (ROS) are common products of bone tissue injury. If ROS cannot be removed in time, oxidative stress will be induced in the cells, which will have a negative effect on the regeneration of bone tissue. In recent years, with the deepening of research, nanomaterials capable of reducing ROS levels have shown increasing potential in promoting bone tissue regeneration. Currently, nanomaterials applied to reduce ROS levels mainly include those with surface modifications and microstructural designs, dopant-modified inorganic materials, functionalized polymeric materials and hydrogels, and nano-enzymatic materials. However, the clinical application of these nanomaterials is still limited due to their potential cytotoxicity and the lack of sufficient clinical trials. This literature review summarises the research on the use of nanomaterials to reduce ROS levels to promote bone regeneration and provides ideas for the future design and development of novel nanomaterials in this field.

Key words: nanomaterials, reactive oxygen species, bone regeneration, antioxidant

中图分类号:

R496

鲁佳艺, 刘锦喆, 郭尚春, 陶诗聪. 纳米材料通过降低活性氧水平促进骨组织再生的研究进展[J]. 上海交通大学学报（医学版）, 2025, 45(4): 487-492.

LU Jiayi, LIU Jinzhe, GUO Shangchun, TAO Shicong. Advances in nanomaterials for promoting bone tissue regeneration by reducing reactive oxygen species levels[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(4): 487-492.

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纳米材料通过降低活性氧水平促进骨组织再生的研究进展

Advances in nanomaterials for promoting bone tissue regeneration by reducing reactive oxygen species levels

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