上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (8): 997-.

• 综述 • 上一篇    下一篇

肝卵圆细胞及其定向诱导分化为胰岛细胞的相关研究

赵丽娟 综述；陆颖理 审校   

  1. 上海交通大学 医学院第九人民医院内分泌代谢科, 上海 200011
  • 出版日期:2009-08-25 发布日期:2009-09-27
  • 作者简介:赵丽娟（1983—）, 女, 硕士生；电子信箱: zhaolijuan83@yahoo.com.cn。

Research progress of hepatic oval cells and differentiation into pancreatic cells

ZHAO Li-Juan reviewer；LU Ying-li reviser   

  1. Department of Endocrinology and Metabolism, The Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, China
  • Online:2009-08-25 Published:2009-09-27

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摘要：

胰岛细胞移植是治愈糖尿病的可能方法，但胰岛细胞数量有限，不能满足临床需要。肝卵圆细胞可以在体外诱导分化为胰岛细胞，因此可以作为胰岛细胞潜在的替代资源。文章就肝卵圆细胞及其定向诱导分化为胰岛细胞的相关研究作一综述。

关键词: 肝卵圆细胞, 胰岛细胞, 活化, 增殖, 分离, 纯化, 鉴定, 诱导分化

Abstract:

Islet cell transplantation is a possible method to cure diabetes mellitus. However, the limited islet resources can not meet the clinical requirement. Hepatic oval cells can be induced in vitro to differentiate into pancreatic cells, and can sever as a potential alternative resource. This article reviews the research progress of hepatic oval cells and differentiation into pancreatic cells.

Key words: hepatic oval cells, pancreatic cells, activation, proliferation, separation, purification, identification, induction and differentiation

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