上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (8): 994-.

• 综述 • 上一篇    下一篇

线粒体DNA与双相障碍发病的相关性研究进展

张 晨 综述；方贻儒 审校   

  1. 上海交通大学 医学院精神卫生中心, 上海 200030
  • 出版日期:2009-08-25 发布日期:2009-09-27
  • 作者简介:张晨（1977—）, 男, 主治医师, 博士生；电子信箱: zhang_chen@msn.com。
  • 基金资助:

    “十五”国家攻关计划(2004BA720A21-02); 国家高技术研究发展计划（“八六三”计划）(2006AA02Z430); 上海市科委基金(064119533)

Research progress of relationship between mitochondrial DNA and bipolar disorder

ZHANG Chen reviewer；FANG Yi-ru reviser   

  1. Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, |China
  • Online:2009-08-25 Published:2009-09-27
  • Supported by:

    National Key Science and Technology Project of “10th Five-Year Plan”, 2004BA720A21-02; National HighTech Research and Development Project, “863” Project, 2006AA02Z430; Shanghai Science and Technology Committee Foundation, 064119533

PDF (PC)

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摘要：

线粒体是细胞能量代谢的中心。人体内线粒体DNA突变可导致细胞氧化磷酸化及能量供应异常，可能与双相障碍的发生有关。文章就线粒体DNA与双相障碍发生的相关性研究进行综述。

关键词: 线粒体DNA, 双相障碍, 突变

Abstract:

Mitochondria are essential elements that generate energy in cells. Mutations of human mitochondrial DNA may lead to aberrant oxidative phosphorylation and energy supplement in cells, indicating a possible relationship with bipolar disorder. The research progress on relationship between mitochondrial DNA and bipolar disorder is reviewed in this paper.

Key words: mitochondrial DNA, bipolar disorder, mutation

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