上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (2): 162-.

• 专题报道（妇科疾病研究） • 上一篇    下一篇

双侧卵巢切除对绝经后妇女绝经期症状的影响

陶敏芳, 朱洁萍, 滕银成   

  1. 上海交通大学 第六人民医院妇产科, 上海 200233
  • 出版日期:2010-02-25 发布日期:2010-02-25
  • 通讯作者: 滕银成, 电子信箱: teng_yc@126.com。
  • 作者简介:陶敏芳（1962—）, 女, 主任医师, 硕士；电子信箱: taomf@126.com。
  • 基金资助:

    上海市卫生局科研基金(2008001)

Impact of bilateral ovariectomy on climacteric symptoms in post-menopausal women

TAO Min-fang, ZHU Jie-ping, TENG Yin-cheng   

  1. Department of Obstetric and Gynecology, The Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2010-02-25 Published:2010-02-25
  • Supported by:

    Shanghai Municipal Health Bureau Foundation, 2008001

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摘要：

目的 研究绝经后女性双侧卵巢切除前后绝经期相关症状的变化。方法 采用自行设计的调查问卷及改良Kupperman评分表对因良性子宫疾病接受子宫切除术加双侧卵巢切除术的绝经后患者进行手术前后绝经期相关症状的评估；并按绝经时间分绝经早期组（绝经时间≤5年）和绝经晚期组（绝经时间＞5年）进行分析和比较。结果 95例研究对象中术前Kupperman评分正常8例、症状轻度46例、中度34例、重度7例；术后评分正常5例，症状轻度28例、中度48例、重度14例；术后中、重度症状者较术前明显增多，差异有统计学意义（P<0.05）。绝经早期组术前Kupperman总分及潮热出汗、失眠、抑郁、疲乏及头痛的症状评分均高于绝经晚期组(P<0.05)。绝经早期组术后Kupperman评分23.93±7.53，显著高于手术前的17.63±8.07(P<0.05），绝经晚期组手术前后Kupperman总分比较差异无统计学意义。结论 双侧卵巢切除对绝经后妇女的绝经期症状有不同程度的影响，对绝经早期妇女的影响较为明显。

关键词: 绝经后, 绝经症状, 双侧卵巢切除术, 改良Kupperman评分

Abstract:

Objective To evaluate the impact of bilateral ovariectomy in post-menopausal women by comparison of climacteric symptoms before and after operation. Methods Post-menopausal women who received hysterectomy with concurrent bilateral ovariectomy on benign uterine indications were recruited. Climacteric symptoms before and after operation were accessed by a questionaire including modified Kupperman Index. Comparison was made after grouping the patients into early menopause group, whose menopausal period was no more than 5 years, and late menopause group, whose menopausal period was more than 5 years. Results Among a total of 95 individuals, 8 had normal, 46 had mild, 34 had moderate, and the other 7 had severe Kupperman Index scores before operation, while 5 had normal, 28 had mild, 48 had moderate, and the other 14 had severe Kupperman Index scores after operation, with more moderate and severe climacteric symptoms after operation than before operation (P<0.05). Women of early menopause group had higher total Kupperman Index scores and symptom scores of sweating, insomnia, depression, fatigue and headache than those of late menopause group before operation (P<0.05). Women of early menopause group had significantly higher Kupperman Index scores after operation than before operation (23.93±7.53 vs 17.63±8.07, P<0.05). However, there was no significant difference in total Kupperman Index scores in women of late menopause group before and after operation. Conclusion Bilateral ovariectomy may affect the climactic symptoms in post-menopausal women, especially in early menopausal period.

Key words: post-menopause, climacteric symptom, bilateral ovariectomy, modified Kupperman Index score