上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (9): 1152-.doi: 10.3969/j.issn.1674-8115.2010.09.032

• 论著（临床研究） • 上一篇    下一篇

血管内皮功能变化与慢性阻塞性肺疾病的关系

郭 瑛, 李燕芹, 刘 斌, 徐佳波, 秦 慧, 邹 静   

  1. 上海交通大学 医学院附属仁济医院呼吸科, 上海 200127
  • 出版日期:2010-09-25 发布日期:2010-09-27
  • 通讯作者: 李燕芹, 电子信箱: drliyanqin@126.com。
  • 作者简介:郭 瑛（1984—）, 女, 硕士生；电子信箱: nisagy@126.com。

Relationship between vascular endothelial function and chronic obstructive pulmonary disease

GUO Ying, LI Yan-qin, LIU Bin, XU Jia-bo, QIN Hui, ZOU Jing   

  1. Department of Respiratory Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2010-09-25 Published:2010-09-27

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摘要：

目的 探讨慢性阻塞性肺疾病(COPD)患者血管内皮功能变化与COPD病情严重程度的相关性。方法 选取2008年5月—2009年3月于仁济医院呼吸科就诊的COPD稳定期患者52例，分为轻度组（n=12）、中度组（n=12）、重度组（n=14）和极重度组（n=14）；以26例健康志愿者作为对照组，分为健康吸烟对照组（n=13）和健康不吸烟对照组（n=13）。所有受试者接受肺功能检测，采用酶联免疫分析法（ELISA）和NO2-/NO3-硝酸还原酶法检测血浆内皮素-1（ET-1）、血管内皮生长因子（VEGF）和血清一氧化氮（NO）浓度。结果 COPD组血清NO和VEGF浓度均低于健康不吸烟对照组，差异有统计学意义（P<0.05）；血清NO和VEGF浓度与第1秒用力呼气容积（FEV1）呈正相关（r=0.767，P<0.01；r=0.658，P<0.01)。COPD组血浆ET-1浓度均高于健康对照组，差异有统计学意义（P<0.05）；血浆ET-1浓度与FEV1呈负相关（r=-0.816，P<0.01)。结论 COPD患者存在血管内皮功能紊乱，且与疾病的严重程度具有相关性。

关键词: 慢性阻塞性肺疾病, 血管内皮细胞, 内皮素-1, 一氧化氮, 血管内皮生长因子

Abstract:

Objective To explore the relationship between vascular endothelial function and severity of chronic obstructive pulmonary disease (COPD). Methods Fifty-two patients with COPD in stable phase visiting Department of Respiratory Medicine, Renji Hospital from May 2008 to March 2009 were selected, and were divided into mild group (n=12), moderate group (n=12), severe group (n=14) and extremely severe group (n=14). Besides, another 26 healthy volunteers were served as control group, and were subdivided into healthy smoking control group (n=13) and healthy non-smoking control group (n=13). Pulmonary function tests were performed in all subjects. Concentrations of plasma endothelin-1 (ET-1), serum vascular endothelial growth factor (VEGF) and serum nitric oxide (NO) were detected by enzyme-linked immunosorbent assay (ELISA) and NO2-／NO3- nitrate reductase assay. Results The concentrations of serum NO and VEGF in COPD groups were significantly lower than those of healthy non-smoking control group (P<0.05). The concentrations of serum NO and VEGF were positively related to forced expiratory volume in one second (FEV1) （r=0.767，P<0.01；r=0.658，P<0.01). The concentrations of plasma ET-1 in COPD groups were significantly higher than those in healthy control groups （P<0.05）. The concentration of plasma ET-1 was negatively related to FEV1 （r=-0.816，P<0.01). Conclusion There exists vascular endothelial dysfunction in patients with COPD, which is closely related to disease severity.

Key words: chronic obstructive pulmonary disease, vascular endothelial cell, endothelin-1, nitrogen oxide, vascular endothelial growth factor