上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (1): 104-.doi: 10.3969/j.issn.1674-8115.2011.01.024

• 综述 • 上一篇    下一篇

肝脏卵圆细胞诱导分化为胰岛β细胞的研究进展

李 影, 陆颖理   

  1. 上海交通大学 医学院附属第九人民医院内分泌代谢科, 上海 2000l1
  • 出版日期:2011-01-28 发布日期:2011-02-01
  • 通讯作者: 陆颖理, 电子信箱: luy662003@yahoo.com.cn。
  • 作者简介:李 影（1984—）, 女, 硕士生；电子信箱: liying1631230@163.com。

Research progress of trans-differentiation of hepatic oval cells into pancreatic beta cells

LI Ying, LU Ying-li   

  1. Department of Endocrinology and Metabolism, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
  • Online:2011-01-28 Published:2011-02-01

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摘要：

肝脏卵圆细胞是具有多向分化潜能的干细胞, 在一定的条件下可诱导分化为胰岛β细胞，葡萄糖、细胞外基质、细胞因子和胰岛转录因子等诸多因素均参与分化过程的调控。文章就肝脏卵圆细胞向胰岛β细胞分化的影响因素进行综述。

关键词: 肝脏卵圆细胞, 胰岛β细胞, 糖尿病, 诱导分化, 影响因素

Abstract:

Hepatic oval cells are pluripotent stem cells, which can be induced to trans-differentiate into pancreatic β cells under certain conditions. Many factors such as diabetes mellitus, extracellular matrix, cytokines and pancreatic islet transcription factor may be involved in the trans-differentiation of hepatic oval cells into pancreatic β cells. This article reviews the influential factors in the trans-differentiation of hepatic oval cells into pancreatic β cells.

Key words: hepatic oval cells, pancreatic &beta, cell, diabetes mellitus, trans-differentiation, influential factor