上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (2): 189-.doi: 10.3969/j.issn.1674-8115.2012.02.014

• 论著（临床研究） • 上一篇    下一篇

高脂血症人群闪光视网膜电图的特征描述

张 蓓, 邱庆华, 王 川, 李圣扬   

  1. 上海交通大学附属第一人民医院眼科, 上海 200080
  • 出版日期:2012-02-28 发布日期:2012-02-28
  • 通讯作者: 邱庆华, 电子信箱: qiuqh9@163.com。
  • 作者简介:张 蓓（1984—）, 女, 硕士生；电子信箱: zhangbeidoctor@126.com。
  • 基金资助:

    上海市眼底病重点实验室开放课题（07Z22911）

Characteristics of flash-electroretinography in patients with hyperlipidemia

ZHANG Bei, QIU Qing-hua, WANG Chuan, LI Sheng-yang   

  1. Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2012-02-28 Published:2012-02-28
  • Supported by:

    Shanghai Key Laboratory for Ocular Fundus Diseases Foundation, 07Z22911

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摘要：

目的 描述高脂血症人群闪光视网膜电图（FERG）特征，探讨高脂血症对视网膜功能的影响。方法 收集2011年2—6月于上海交通大学附属第一人民医院体检中心确诊为高脂血症的124例患者为高脂血症组，以同期常规体检的60名健康者为正常对照组。对两组受试者进行F-ERG检查，记录视杆细胞反应的a波（Rod-a）和b波（Rod-b）、最大综合反应的a波（Max-a）和b波（Max-b）、振荡电位（Ops）、视锥细胞反应的a波（Cone-a）和b波（Cone-b）以及30 Hz闪烁光反应的b波（Flicker-b）。比较两组间F-ERG 5项标准反应各子波的波幅、潜伏期以及Max-b与Max-a波幅比值（b/a）的差异。结果 高脂血症组F-ERG 5项标准反应各子波的波幅均显著低于正常对照组，差异有统计学意义（P<0.01）；除Max-b波潜伏期略延长外（P<0.05），高脂血症组其余各子波潜伏期均较正常对照组显著延长，差异有统计学意义（P<0.01）。高脂血症组Max-b与Max-a波幅比值（b/a）显著高于正常对照组，差异有统计学意义（P<0.01）。结论 高脂血症患者的视网膜功能明显受损，且视网膜外层功能较内层受损严重。

关键词: 高脂血症, 视网膜, 视网膜电图

Abstract:

Objective To describe the characteristics of flash-electroretinography (F-ERG) in patients with hyperlipidemia, and investigate the effect of hyperlipidemia on the retinal function. Methods One hundred and twenty-four patients with hyperlipidemia diagnosed at the First People's Hospital affiliated to Shanghai Jiaotong University between February 2011 and June 2011 were selected as hyperlipidemia group, and another 60 healthy people were served as normal control group. F-ERG was performed in both groups, and a wave and b wave of rod cell response (Rod-a and Rod-b), a wave and b wave of maximum response (Max-a and Max-b), oscillatory potentials (Ops), a wave and b wave of cone cell response (Cone-a and Cone-b) and b wave of 30 Hz flicker response (Flicker-b) were recorded. The wave amplitudes and latencies of 5 items of standard F-ERG and the ratios of wave amplitude of Max-b to that of Max-a (b/a) were compared between two groups. Results The wave amplitudes of 5 items of standard F-ERG in hyperlipidemia group were significantly lower than those in normal control group (P<0.01). The latency of Max-b wave of standard F-ERG in hyperlipidemia group was slightly longer than that in normal control group (P<0.05), and the wave latencies of the other 4 items of standard F-ERG in hyperlipidemia group were significantly longer than those in normal control group (P<0.01). The ratios of wave amplitude of Max-b to that of Max-a (b/a) in hyperlipidemia group were significantly higher than those in normal control group (P<0.01). Conclusion The retinal function of patients with hyperlipidemia is significantly impaired, and the damage in outer layer of retina is more severe than that in inner layer of retina.

Key words: hyperlipidemia, retina, electroretinography