上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (2): 214-.doi: 10.3969/j.issn.1674-8115.2012.02.020

• 综述 • 上一篇    下一篇

肿瘤抑素抑制血管生成作用的研究进展

马莹琰, 邹海东   

  1. 上海交通大学附属第一人民医院眼科, 上海 200080
  • 出版日期:2012-02-28 发布日期:2012-02-28
  • 作者简介:马莹琰（1988—）, 女, 硕士生；电子信箱: myy_29@163.com。
  • 基金资助:

    上海市科委白玉兰科研基金 (11BA1409700)；上海交通大学医学院自然科学研究基金(11XJ21056)；上海市眼底病重点实验室开放课题基金（07Z22911）

Research progress of antiangiogenic activity of tumstatin

MA Ying-yan, ZOU Hai-dong   

  1. Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2012-02-28 Published:2012-02-28
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 11BA1409700；Shanghai Jiaotong University School of Medicine Foundation, 11XJ21056；Shanghai Key Laboratory for Ocular Fundus Diseases Foundation, 07Z22911

PDF (PC)

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摘要：

肿瘤抑素是一种能够有效抑制肿瘤新生血管和肿瘤细胞增殖的生物活性物质，通过双重途径抑制肿瘤生长，具有较强的肿瘤生长抑制作用。肿瘤抑素的生物活性和作用机制逐渐得到揭示，文章对其抗新生血管的活性和作用机制进行综述，并展望其在眼科的应用前景。

关键词: 肿瘤抑素, Ⅳ型胶原α3链, 血管生成

Abstract:

Tumstatin is a bioactivator which can effectively suppress tumor growth by inhibiting both angiogenesis of tumor vessels and proliferation of tumor cells. Tumstatin has great ability to cause tumor stasis. The bioactivity and mechanisms  of tumstatin have been gradually revealed. The antiangiogenic activity and mechanisms of tumstatin are reviewed in this paper, and the prospect of application of tumstatin in ophthalmology is explored.

Key words: tumstatin, type Ⅳ collagen alpha3 chain, angiogenesis