上海交通大学学报（医学版）

上海交通大学学报（医学版）

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艰难梭菌感染的流行状况及耐药机制研究进展

李 贞，章黎华，董丹凤，江 岑，彭奕冰   

  1. 上海交通大学 医学院附属瑞金医院检验科， 上海 200025
  • 出版日期:2014-06-28 发布日期:2014-06-30
  • 通讯作者: 彭奕冰, 电子信箱: pyb9861@sohu.com。
  • 作者简介:李 贞(1988—)， 女， 硕士生; 电子信箱: lizhen929@126.com。
  • 基金资助:

    上海市科委基础重点项目（12JC1406100）

Advances of epidemiology and resistance mechanism of Clostridium difficile infection

LI Zhen, ZHANG Li-hua, DONG Dan-feng, JIANG Cen, PENG Yi-bing   

  1. Department of Clinical Laboratory， Ruijin Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China
  • Online:2014-06-28 Published:2014-06-30
  • Supported by:

    Key Basic Research Project of Science and Technology Commission of Shanghai Municipality, 12JC1406100

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摘要：

近年来艰难梭菌感染（CDI）的流行状况发生了巨大变化，随着其感染率的增加及病情的加剧，CDI已成为一个全球性的健康问题。CDI曾在北美和欧洲数次暴发流行，同样艰难梭菌也已成为亚洲地区重要的院内感染病原体，但目前国内对CDI的认识和临床感染监控还不够。了解CDI的流行状况和艰难梭菌耐药情况，可以为临床预防及治疗CDI提供依据。本文将就CDI的流行状况及耐药机制的研究进展进行综述。

关键词: 艰难梭菌, 流行病学, 耐药机制, 毒力因子

Abstract:

In recent years, with the dramatic changes in the epidemiology of Clostridium difficile infection (CDI) as well as increases in incidence and severity of the disease, CDI has become a global public health challenge. There have been several outbreaks of CDI in North America and Europe and Clostridium difficile has also become an important pathogenic cause of nosocomial infection in Asia. However, the awareness and surveillance of CDI still remain poor in China. A better knowledge of the epidemiology of CDI and antimicrobial resistance of Clostridium difficile can provide the basis for the prevention and treatment of CDI. This paper reviews the epidemiology and research progresses of resistance mechanism of CDI.

Key words: Clostridium difficile, epidemiology, resistance mechanisms, virulence factors