上海交通大学学报（医学版）

上海交通大学学报（医学版）

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长链非编码RNA调控胃癌侵袭和转移的研究进展

潘涛， 俞振佳， 吴熊焰， 苏丽萍   

  1. 上海交通大学 医学院附属瑞金医院 上海消化外科研究所， 上海 200025
  • 出版日期:2016-09-28 发布日期:2016-10-31
  • 作者简介:潘涛（1991—）， 男， 硕士生； 电子信箱： pantaolove@foxmail.com。
  • 基金资助:

    上海市教育委员会高峰高原学科建设计划（20152505）

Research progresses of regulating the invasion and metastasis of gastric cancer by long non-coding RNA

PAN Tao, YU Zhen-jia, WU Xiong-yan, SU Li-ping   

  1. Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2016-09-28 Published:2016-10-31
  • Supported by:

    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support， 20152505

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摘要：

胃癌是亚洲常见的消化道恶性道肿瘤之一，容易发生淋巴转移和血液转移。肿瘤远处转移是胃癌患者的主要死亡原因，但目前胃癌侵袭转移的分子机制尚未完全阐明。长链非编码RNA是一类长度大于200 nt、缺少开放阅读框的非编码RNA分子，在免疫反应、干细胞多能性、细胞的增殖凋亡和分化等多种生物过程中发挥着重要作用。近年来研究显示长链非编码RNA与胃癌的侵袭、转移和患者的预后密切相关，长链非编码RNA能通过多种途径调节胃癌细胞的侵袭和转移能力。该文对长链非编码RNA调控胃癌侵袭转移的最新研究进展作一综述。

关键词: 胃癌, 长链非编码RNA, 侵袭, 转移

Abstract:

Gastric cancer is one of the most common digestive tract malignancies in Asia and prones to lymph node metastasis and hematogenous metastasis. Tumor remote metastasis is the main cause of death in patients with gastric cancer, while the molecular mechanism underlying the invasion and metastasis is still not fully clarified. Long non-coding RNA is a class of non-coding RNA molecules with a length of more than 200 nt and lack of open reading frames. Numerous studies have shown that long non-coding RNA plays an important role in multiple biological processes, including immune response, pluripotency of stem cells, and cell proliferation, apoptosis, and differentiation. Recent research indicated that long non-coding RNA is closely associated with invasion, metastasis, and prognosis of gastric cancer, as well as regulation of tumor invasion and metastasis through multiple pathways. This article reviews the latest research progresses of regulating the invasion and metastasis of gastric cancer by long non-coding RNA.

Key words: gastric cancer, long non-coding RNA, invasion, metastasis