上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

脂肪组织chemerin及其受体chemerinR基因表达与肥胖及2型糖尿病的关系

王玲艳 1，于浩泳 2，魏丽 2   

  1. 1.上海市奉贤区中心医院内分泌代谢科，上海 201400；2.上海交通大学附属第六人民医院内分泌代谢科，上海市糖尿病研究所，上海 200233
  • 出版日期:2017-03-28 发布日期:2017-03-30
  • 作者简介:王玲艳（1985—），女，硕士生；电子信箱：wangly0922@qq.com。
  • 基金资助:

    国家自然科学基金（30670989）

Relationship of adipose chemerin and its receptor chemerinR gene expression to obesity and type 2 diabetes mellitus

WANG Ling-yan1, YU Hao-yong2, WEI Li2   

  1. 1. Department of Endocrinology and Metabolism, Shanghai Fengxian District Central Hospital, Shanghai 201400, China; 2. Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai Diabetes Institute, Shanghai 200233, China
  • Online:2017-03-28 Published:2017-03-30
  • Supported by:

    National Natural Science Foundation of China, 30670989

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摘要：

目的 ·探讨中国汉族人群中chemerin及其受体chemerinR与肥胖及2型糖尿病的关系。方法 ·收集24名腹部择期手术患者作为研究对象，按照体质量指数（BMI）分为正常糖调节正常体重组（NGR-NW）、正常糖调节超重/肥胖组（NGR-OW/OB）和2型糖尿病超重/肥胖组（T2DM-OW/OB）。采用RT-PCR法测定腹部皮下脂肪组织和腹内网膜脂肪组织中chemerin、chemerinR mRNA水平。结果 · NGR-OW/OB组和T2DM-OW/OB组腹部皮下脂肪组织和腹内网膜脂肪组织中chemerin mRNA水平均显著高于NGR-NW组（P<0.05）。相关分析显示，网膜脂肪组织chemerin mRNA水平与BMI、空腹胰岛素（FINS）、三酰甘油和血清chemerin浓度呈正相关（r分别为0.577、0.561、0.472、0.623，P均<0.05）；腹部皮下脂肪组织中chemerin mRNA水平与BMI、FINS、血清chemerin浓度呈正相关（r分别为0.692、0.513、0.497，P均<0.05）。结论 ·网膜脂肪组织、皮下脂肪组织的chemerin mRNA的表达量均与BMI、FINS、血清 chemerin浓度呈正相关，提chemerin基因可能在肥胖及2型糖尿病的病理生理机制中发挥一定作用。

关键词: chemerin基因, chemerinR基因, 肥胖, 2型糖尿病

Abstract:

Objective · To explore the relationship of adipose chemerin and its receptor chemerinR gene expression to obesity and type 2 diabetes mellitus. Methods · Twenty-four patients undergoing elective abdominal surgery were enrolled, and were divided into normal glucose regulation-normal weight group (NGR-NW), normal glucose regulation-overweight/obesity group (NGR-OW/OB), and type 2 diabetic overweight/obesity group (T2DMOW/OB) according to the body mass index (BMI). The levels of chemerin and chemerinR mRNA were detected by reverse transcription PCR (RT-PCR). Results · Compare to the NGR-NW group, the chemerin mRNA levels of abdominal subcutaneous and omental fat were significantly increased in the NGR-OW/OB and T2DM-OW/OB group (P<0.05). Correlation analysis showed that the chemerin mRNA levels of abdominal omental fat were positively correlated with BMI, fasting insulin (FINS), triglyceride and serum chemerin (r=0.577, r=0.561, r=0.472, r=0.623, P<0.05 for all). The chemerin mRNA levels of abdominal subcutaneous fat showed significant positive correlation with BMI, FINS and serum chemerin (r=0.692, r=0.513, r=0.497, P<0.05 for all). Conclusion · The chemerin mRNA levels of abdominal subcutaneous and omental fat were positively correlated with BMI, FINS and serum chemerin, suggesting that the chemerin gene may play a crucial role in the pathophysiological mechanism of obesity and type 2 diabetes.

Key words: chemerin gene, chemerinR gene, obesity, type 2 diabetes mellitus