上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (6): 809-.doi: 10.3969/j.issn.1674-8115.2017.06.017

• 论著（临床研究） • 上一篇    下一篇

上海市嘉定区中老年非糖尿病人群颈围与心血管危险因素的  相关性研究

刘珊珊，汪龙，丁琳，彭魁，徐瑜，徐敏，陆洁莉，毕宇芳，王卫庆，宁光   

  1. 国家代谢性疾病临床医学研究中心，上海市内分泌代谢病研究所，上海交通大学 医学院附属瑞金医院内分泌代谢病科，上海 200025
  • 出版日期:2017-06-28 发布日期:2017-07-05
  • 作者简介:刘珊珊（1991—），女，硕士生；电子信箱：17605366670@163.com
  • 基金资助:

    上海市教育委员会高峰高原学科建设计划（20161301）

Association between neck circumference and cardiovascular risk factors in middle-aged and elderly nondiabetic people in Jiading District, Shanghai

LIU Shan-shan, WANG Long, DING Lin, PENG Kui, XU Yu, XU Min, LU Jie-li, BI Yu-fang, WANG Wei-qing, NING Guang   

  1. Shanghai Clinical Center for Endocrine and Metabolic Diseases; Shanghai Institute of Endocrine and Metabolic Diseases; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2017-06-28 Published:2017-07-05
  • Supported by:

    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20161301

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摘要：

目的 · 探讨上海市嘉定区中老年非糖尿病人群颈围与心血管危险因素的相关性。方法 · 2014 年 8 月—2015 年 7 月选取上海市 嘉定区 4 657 名 40 岁及以上非糖尿病常住居民，进行问卷调查、体格检查和生化指标检测。按照颈围四分位数分组，分析颈围与心血 管危险因素的相关性。结果 · 随着颈围的增粗，腰围、体质量指数（BMI）、血压、血脂、空腹血糖、胰岛素抵抗指数水平升高，腹型 肥胖、胰岛素抵抗、高血压和血脂异常发生率显著增加（均趋势 P 值<0.01）。多元 Logistic 回归分析显示，校正年龄、性别、吸烟、 饮酒、体力活动、BMI、腰围、收缩压、C- 反应蛋白、空腹血糖和血脂等因素后，随着颈围的增粗，各心血管相关危险因素的发生风 险均显著增加（均趋势 P 值<0.01）。 结论 · 上海市嘉定区中老年非糖尿病人群中，颈围与各心血管危险因素呈独立正相关。

关键词: 颈围, 心血管危险因素, 非糖尿病人群, 腹型肥胖, 胰岛素抵抗, 高血压, 血脂异常

Abstract:

 Objective · To investigate the association between neck circumference (NC) and cardiovascular risk factors among middle-aged and elderly people without diabetes in Jiading District in Shanghai.  Methods · A cross-sectional study was conducted among 4 657 nondiabetic inhabitants aged 40 and above in Jiading District, Shanghai from August 2014 to July 2015. Clinical information collection, anthropometric measurements, and biochemical analyses were performed. The objects were divided into 4 groups according to the quartiles of NC in order to analyze association between NC and cardiovascular risk factors.  Results · With increase of NC, the prevalences of abdominal obesity, insulin resistance, hypertension, and dyslipidemia all increased as well as waist circumference, body mass index (BMI), blood pressure, lipid profile, fast blood glucose, and HOMA-IR level (all Ptrend <0.01). Multiple Logistic regression analysis showed that individuals in Q2, Q3 and Q4 group had significantly higher risk of abdominal obesity, insulin resistance, hypertension, and dyslipidemia compared with those in Q1 group after age, sex, smoking, drinking, physical activity, BMI, waist circumference, systolic blood pressure, C-reactive protein, fast blood glucose, and lipid profile were corrected (all Ptrend <0.01).  Conclusion · NC is positively and independently correlated with cardiovascular risk factors in middle-aged and elderly nondiabetic people in Jiading District in Shanghai.

Key words:  neck circumference, cardiovascular risk factor, nondiabetic population, abdominal obesity, insulin resistance, hypertension, dyslipidemia